Steroidogenesis in Peripheral and Transition Zones of Human Prostate Cancer Tissue.
backdoor pathway
classical pathway
liquid chromatography-mass spectrometry
prostate cancer
prostate tissue metabolism
steroidogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Jan 2021
06 Jan 2021
Historique:
received:
30
11
2020
revised:
28
12
2020
accepted:
30
12
2020
entrez:
9
1
2021
pubmed:
10
1
2021
medline:
3
9
2021
Statut:
epublish
Résumé
The peripheral zone (PZ) and transition zone (TZ) represent about 70% of the human prostate gland with each zone having differential ability to develop prostate cancer. Androgens and their receptor are the primary driving cause of prostate cancer growth and eventually castration-resistant prostate cancer (CRPC). De novo steroidogenesis has been identified as a key mechanism that develops during CRPC. Currently, there is very limited information available on human prostate tissue steroidogenesis. The purpose of the present study was to investigate steroid metabolism in human prostate cancer tissues with comparison between PZ and TZ. Human prostate cancer tumors were procured from the patients who underwent radical prostatectomy without any neoadjuvant therapy. Human prostate homogenates were used to quantify steroid levels intrinsically present in the tissues as well as formed after incubation with 2 µg/mL of 17-hydroxypregnenolone (17-OH-pregnenolone) or progesterone. A Waters Acquity ultraperformance liquid chromatography coupled to a Quattro Premier XE tandem quadrupole mass spectrometer using a C
Identifiants
pubmed: 33418978
pii: ijms22020487
doi: 10.3390/ijms22020487
pmc: PMC7825320
pii:
doi:
Substances chimiques
Steroids
0
Testosterone
3XMK78S47O
Androstenedione
409J2J96VR
Progesterone
4G7DS2Q64Y
Androsterone
C24W7J5D5R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Glaxo SmithKline (GSK)
ID : GSK
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