Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics.
drug delivery
gene delivery
immunotherapy
microneedle arrays
nanomedicine
vaccination
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
06 Jan 2021
06 Jan 2021
Historique:
received:
28
11
2020
revised:
25
12
2020
accepted:
28
12
2020
entrez:
9
1
2021
pubmed:
10
1
2021
medline:
10
1
2021
Statut:
epublish
Résumé
Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challenging. Microneedle array (MN) technology has recently revealed promising outcomes in the delivery of various formulations, especially NPs to deliver both hydrophilic and hydrophobic therapeutic agents. The present work reviews the advancements in the application of MNs and NPs for an effective transdermal delivery of a wide range of therapeutics in cancer chemotherapy and immunotherapy, photothermal and photodynamic therapy, peptide/protein vaccination, and the gene therapy of various diseases. In addition, this paper provides an overall insight on MNs' challenges and summarizes the recent achievements in clinical trials with future outlooks on the transdermal delivery of a wide range of nanomedicines.
Identifiants
pubmed: 33419118
pii: jcm10020181
doi: 10.3390/jcm10020181
pmc: PMC7825522
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Shiraz University of Medical Sciences
ID : 16940
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interests.
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