Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1

Adenocarcinoma / drug therapy Adenocarcinoma, Clear Cell / drug therapy Antibodies, Monoclonal, Humanized / therapeutic use CTLA-4 Antigen / metabolism Humans Immunotherapy Kidney Neoplasms / drug therapy Male Middle Aged Programmed Cell Death 1 Receptor / metabolism Stomach Neoplasms / drug therapy T-Lymphocytes / immunology

Journal

Cancer discovery

ISSN: 2159-8290

Titre abrégé: Cancer Discov

Pays: United States

ID NLM: 101561693

Informations de publication

Date de publication:
05 2021

Historique:

received: 13 10 2020

revised: 04 12 2020

accepted: 17 12 2020

pubmed: 10 1 2021

medline: 29 1 2022

entrez: 9 1 2021

Statut: ppublish

Résumé

The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent bispecific antibody designed to suppress the PD-1 pathway and provide modulated CTLA4 inhibition favoring enhanced blockade on PD-1

Identifiants

DOI: 10.1158/2159-8290.CD-20-1445 PMID: 33419761

pubmed: 33419761

pii: 2159-8290.CD-20-1445

doi: 10.1158/2159-8290.CD-20-1445

doi:

Substances chimiques

Antibodies, Monoclonal, Humanized 0

CTLA-4 Antigen 0

CTLA4 protein, human 0

Programmed Cell Death 1 Receptor 0

Tovetumab 2XY62K75UV

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

1100-1117

Commentaires et corrections

Type : CommentIn

Informations de copyright

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