Probing tissue microstructure by diffusion skewness tensor imaging.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
08 01 2021
08 01 2021
Historique:
received:
30
06
2020
accepted:
30
11
2020
entrez:
9
1
2021
pubmed:
10
1
2021
medline:
15
9
2021
Statut:
epublish
Résumé
Probing the cellular structure of in vivo biological tissue is a fundamental problem in biomedical imaging and medical science. This work introduces an approach for analyzing diffusion magnetic resonance imaging data acquired by the novel tensor-valued encoding technique for characterizing tissue microstructure. Our approach first uses a signal model to estimate the variance and skewness of the distribution of apparent diffusion tensors modeling the underlying tissue. Then several novel imaging indices, such as weighted microscopic anisotropy and microscopic skewness, are derived to characterize different ensembles of diffusion processes that are indistinguishable by existing techniques. The contributions of this work also include a theoretical proof that shows that, to estimate the skewness of a diffusion tensor distribution, the encoding protocol needs to include full-rank tensor diffusion encoding. This proof provides a guideline for the application of this technique. The properties of the proposed indices are illustrated using both synthetic data and in vivo data acquired from a human brain.
Identifiants
pubmed: 33420140
doi: 10.1038/s41598-020-79748-3
pii: 10.1038/s41598-020-79748-3
pmc: PMC7794496
doi:
Types de publication
Evaluation Study
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
135Subventions
Organisme : NIMH NIH HHS
ID : R01 MH116173
Pays : United States
Organisme : NIMH NIH HHS
ID : K01 MH117346
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH115280
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119222
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH074794
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH116352
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111917
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015902
Pays : United States
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