DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
27
01
2020
accepted:
04
12
2020
revised:
04
11
2020
pubmed:
10
1
2021
medline:
12
10
2021
entrez:
9
1
2021
Statut:
ppublish
Résumé
DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of epigenome-wide association studies (EWAS) of aggressive behavior (N = 15,324 participants). In peripheral blood samples of 14,434 participants from 18 cohorts with mean ages ranging from 7 to 68 years, 13 methylation sites were significantly associated with aggression (alpha = 1.2 × 10
Identifiants
pubmed: 33420481
doi: 10.1038/s41380-020-00987-x
pii: 10.1038/s41380-020-00987-x
pmc: PMC8263810
mid: EMS114691
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2148-2162Subventions
Organisme : Medical Research Council
ID : MR/R005176/1
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : R01 MH062873
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS047537
Pays : United States
Organisme : European Research Council
ID : 230374
Pays : International
Organisme : NIA NIH HHS
ID : R01 AG028555
Pays : United States
Organisme : Medical Research Council
ID : G1002190
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK103246
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA012502
Pays : United States
Organisme : MRF
ID : MRF_C0396
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008924/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG010175
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032282
Pays : United States
Organisme : Medical Research Council
ID : MR/K013807/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P005918/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : R01 HD077482
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG009453
Pays : United States
Organisme : European Research Council
ID : 268479
Pays : International
Organisme : Wellcome Trust
ID : 088806
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J000914/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102215
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : N01ES75558
Pays : United States
Investigateurs
Bastiaan T Heijmans
(BT)
Peter A C 't Hoen
(PAC)
Joyce van Meurs
(J)
Rick Jansen
(R)
Lude Franke
(L)
Dorret I Boomsma
(DI)
René Pool
(R)
Jenny van Dongen
(J)
Jouke J Hottenga
(JJ)
Marleen M J van Greevenbroek
(MMJ)
Coen D A Stehouwer
(CDA)
Carla J H van der Kallen
(CJH)
Casper G Schalkwijk
(CG)
Cisca Wijmenga
(C)
Lude Franke
(L)
Sasha Zhernakova
(S)
Ettje F Tigchelaar
(EF)
P Eline Slagboom
(PE)
Marian Beekman
(M)
Joris Deelen
(J)
Diana van Heemst
(D)
Jan H Veldink
(JH)
Leonard H van den Berg
(LH)
Cornelia M van Duijn
(CM)
Bert A Hofman
(BA)
Aaron Isaacs
(A)
André G Uitterlinden
(AG)
Joyce van Meurs
(J)
P Mila Jhamai
(PM)
Michael Verbiest
(M)
H Eka D Suchiman
(HED)
Marijn Verkerk
(M)
Ruud van der Breggen
(R)
Jeroen van Rooij
(J)
Nico Lakenberg
(N)
Hailiang Mei
(H)
Maarten van Iterson
(M)
Michiel van Galen
(M)
Jan Bot
(J)
Dasha V Zhernakova
(DV)
Rick Jansen
(R)
Peter van 't Hof
(P)
Patrick Deelen
(P)
Irene Nooren
(I)
Peter A C 't Hoen
(PAC)
Bastiaan T Heijmans
(BT)
Matthijs Moed
(M)
Lude Franke
(L)
Martijn Vermaat
(M)
Dasha V Zhernakova
(DV)
René Luijk
(R)
Marc Jan Bonder
(M)
Maarten van Iterson
(M)
Patrick Deelen
(P)
Freerk van Dijk
(F)
Michiel van Galen
(M)
Wibowo Arindrarto
(W)
Szymon M Kielbasa
(SM)
Morris A Swertz
(MA)
Erik W van Zwet
(EW)
Rick Jansen
(R)
Peter-Bram 't Hoen
(PB)
Bastiaan T Heijmans
(BT)
Informations de copyright
© 2021. The Author(s).
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