Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer's disease.
Alzheimer’s disease (AD)
Dementia
Late-onset Alzheimer’s disease (LOAD)
Neuropsychiatric Inventory–Questionnaire (NPI-Q)
Neuropsychiatric symptoms (NPS)
Young-onset Alzheimer’s disease (YOAD)
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
10
09
2020
accepted:
18
11
2020
pubmed:
10
1
2021
medline:
1
6
2021
entrez:
9
1
2021
Statut:
ppublish
Résumé
Young-onset and late-onset Alzheimer's disease has different clinical presentations with late-onset presenting most often with memory deficits while young-onset often presents with a non-amnestic syndrome. However, it is unknown whether there are differences in presentation and progression of neuropsychiatric symptoms in young- versus late-onset Alzheimer's disease. We aimed to investigate differences in the prevalence and severity of neuropsychiatric symptoms in patients with young- and late-onset Alzheimer's disease longitudinally with and without accounting for the effect of medication usage. Sex differences were also considered in these patient groups. We included 126 young-onset and 505 late-onset Alzheimer's disease patients from National Alzheimer's Coordinating Center-Uniform Data Set (NACC-UDS) and Alzheimer's Disease Neuroimaging Initiative (ADNI). We investigated the prevalence and severity of neuropsychiatric symptoms using the Neuropsychiatric Inventory-Questionnaire over 4 visits with 1-year intervals, using a linear mixed-effects model. The prevalence of depression was significantly higher in young-onset than late-onset Alzheimer's disease over a 4-year interval when antidepressant usage was included in our analyses. Our findings suggest that neuropsychiatric symptom profiles of young- and late-onset Alzheimer's disease differ cross-sectionally but also display significant differences in progression.
Identifiants
pubmed: 33420706
doi: 10.1007/s11357-020-00304-y
pii: 10.1007/s11357-020-00304-y
pmc: PMC8050126
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
213-223Subventions
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016573
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ID : P30 AG062422
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ID : P30 AG019610
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