Late recurrence of cancer stem cell-positive colorectal cancer liver metastases after 15 years.
Cancer stem cell
Colorectal cancer
Late recurrence
Liver metastasis
Journal
Clinical journal of gastroenterology
ISSN: 1865-7265
Titre abrégé: Clin J Gastroenterol
Pays: Japan
ID NLM: 101477246
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
07
10
2020
accepted:
21
12
2020
pubmed:
10
1
2021
medline:
29
6
2021
entrez:
9
1
2021
Statut:
ppublish
Résumé
No cases of late recurrence of colorectal cancer liver metastasis (CRLM) over 10 years have been reported in the literature. A 72-year-old woman had a surgical history of sigmoid colectomy and partial hepatic resections for sigmoid colon cancer and multiple liver metastases 15 years previously. The patient had been postoperatively treated with chemotherapy for 6 months and was observed regularly with no recurrence. Computed tomography (CT) performed due to high carcinoembryonic antigen (CEA) revealed a tumor of 70 mm in diameter at the anterior segment of the liver and a 6-mm nodule at the left lateral segment. There was no other malignant finding. We performed central bisegmentectomy and partial resection of the liver. Pathological findings showed the tumors to be well to moderately differentiated adenocarcinoma, and positive cytokeratin 20 (CK20) and caudal-type homeobox transcription factor 2 (CDX2) expression with negative expression of cytokeratin 7 (CK7). In addition, the tumors showed cluster of differentiation 44 (CD44) and 133 (CD133) positive signified cancer stem cell immunohistochemically. The postoperative diagnosis was recurrence of hepatic metastasis of sigmoid colon cancer. We report a rare case of late recurrence of CRLM more than 15 years after the primary diagnosis.
Identifiants
pubmed: 33421028
doi: 10.1007/s12328-020-01330-1
pii: 10.1007/s12328-020-01330-1
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
613-616Références
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34.
doi: 10.3322/caac.21551
Lopez P, Marzano E, Piardi T, et al. Repeat hepatectomy for liver metastases from colorectal primary cancer: a review of the literature. J Visc Surg. 2012;149:e97–103.
doi: 10.1016/j.jviscsurg.2012.01.001
Nordlinger B, Sorbye H, Glimelius B, et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2013;14:1208–15.
doi: 10.1016/S1470-2045(13)70447-9
de Jong MC, Mayo SC, Pulitano C, et al. Repeat curative intent liver surgery is safe and effective for recurrent colorectal liver metastasis: results from an international multi-institutional analysis. J Gastrointest Surg. 2009;13:2141–51.
doi: 10.1007/s11605-009-1050-0
Metcalfe MS, Mullin EJ, Maddern GJ. Choice of surveillance after hepatectomy for colorectal metastases. Arch Surg. 2004;139:749–54.
doi: 10.1001/archsurg.139.7.749
Pulitanó C, Castillo F, Aldrighetti L, et al. What defines “cure” after liver resection for colorectal metastases? Results after 10 years of follow-up. Hpb. 2010;12:244–9.
doi: 10.1111/j.1477-2574.2010.00155.x
Gao XL, Zhang M, Tang YL, et al. Cancer cell dormancy: mechanisms and implications of cancer recurrence and metastasis. Onco Targets Ther. 2017;10:5219–28.
doi: 10.2147/OTT.S140854
Mitry E, Fields ALA, Bleiberg H, et al. Adjuvant chemotherapy after potentially curative resection of metastases from colorectal cancer: a pooled analysis of two randomized trials. J Clin Oncol. 2008;26:4906–11.
doi: 10.1200/JCO.2008.17.3781
Kow AWC. Hepatic metastasis from colorectal cancer. J Gastrointest Oncol. 2019;10:1274–98.
doi: 10.21037/jgo.2019.08.06
Wang SJ, Si XY, Cai ZB, et al. Survival after repeat hepatectomy for recurrent colorectal liver metastasis: a review and meta-analysis of prognostic factors. Hepatobiliary Pancreat Dis Int. 2019;18:313–20.
doi: 10.1016/j.hbpd.2019.02.003
Colvin HS, Nishida N, Koseki J, et al. Cancer stem cells of the digestive system. Jpn J Clin Oncol. 2014;44:1141–9.
doi: 10.1093/jjco/hyu146
Okamura R, Hida K, Nishizaki D, et al. Proposal of a stage-specific surveillance strategy for colorectal cancer patients: a retrospective analysis of Japanese large cohort. Eur J Surg Oncol. 2018;44:449–55.
doi: 10.1016/j.ejso.2018.01.080
Van Der Stok EP, Spaander MCW, Grünhagen DJ, et al. Surveillance after curative treatment for colorectal cancer. Nat Rev Clin Oncol. 2017;14:297–315.
doi: 10.1038/nrclinonc.2016.199