Bisphenol S is present in culture media used for ART and cell culture.
assisted reproduction
cell culture / plastic consumables / bisphenols / culture media
endocrine disruptors
female infertility
oocyte quality
Journal
Human reproduction (Oxford, England)
ISSN: 1460-2350
Titre abrégé: Hum Reprod
Pays: England
ID NLM: 8701199
Informations de publication
Date de publication:
18 03 2021
18 03 2021
Historique:
received:
29
06
2020
revised:
08
12
2020
pubmed:
10
1
2021
medline:
29
5
2021
entrez:
9
1
2021
Statut:
ppublish
Résumé
Do plastic laboratory consumables and cell culture media used in ART contain bisphenols? The majority of human embryo culture media assessed contained bisphenol S close to the nanomolar concentration range, while no release of bisphenols by plastic consumables was detected under routine conditions. The deleterious effect of the endocrine disruptor bisphenol A (BPA) on female fertility raised concerns regarding ART outcome. BPA was detected neither in media nor in the majority of plastic consumables used in ART; however, it might have already been replaced by its structural analogs, including bisphenol S (BPS). Seventeen plastic consumables and 18 cell culture and ART media were assessed for the presence of bisphenols. Ten different bisphenols (bisphenol A, S, AF, AP, B, C, E, F, P and Z) were measured using an isotopic dilution according to an on-line solid phase extraction/liquid chromatography/mass spectrometry method. While the plastic consumables did not release bisphenols under routine conditions, 16 of the 18 cell culture and ART media assessed contained BPS. Six media exhibited BPS concentrations higher than 1 nM and reached up to 6.7 nM (1693 ng/l). N/A. Further studies are required to investigate a greater number of ART media to identify less potentially harmful ones, in terms of bisphenol content. As BPS has already been reported to impair oocyte quality at nanomolar concentrations, its presence in ART media, at a similar concentration range, could contribute to a decrease in the ART success rate. Thus far, there has been no regulation of these compounds in the ART context. This study was financially supported by the 'Centre-Val de Loire' Region (Bemol project, APR IR 2017), INRAE, BRGM, the French National Research Agency (project ANR-18-CE34-0011-01 MAMBO) and the BioMedicine Agency (Project 18AMP006 FertiPhenol). The authors declare that they have no conflict of interest that could be perceived as prejudicing the impartiality of the reported research.
Identifiants
pubmed: 33421069
pii: 6075090
doi: 10.1093/humrep/deaa365
pmc: PMC7970731
doi:
Substances chimiques
Benzhydryl Compounds
0
Culture Media
0
Endocrine Disruptors
0
Phenols
0
Sulfones
0
bis(4-hydroxyphenyl)sulfone
80-09-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1032-1042Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.
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