NRG/ErbB signaling regulates neonatal muscle growth but not neuromuscular contractures in neonatal brachial plexus injury.
Animals
Animals, Newborn
Brachial Plexus
/ drug effects
Contracture
/ genetics
ErbB Receptors
/ antagonists & inhibitors
Gene Expression Regulation
Mice
Morpholines
/ pharmacology
Muscle Denervation
/ methods
Muscle Development
/ genetics
Muscle, Skeletal
/ cytology
Muscular Atrophy
/ genetics
Neuregulin-1
/ genetics
Neuromuscular Junction
/ drug effects
Signal Transduction
ErbB
denervation
muscle atrophy
muscle development
muscle growth
neonatal brachial plexus injury
neuregulin
neuromuscular contractures
Journal
FEBS letters
ISSN: 1873-3468
Titre abrégé: FEBS Lett
Pays: England
ID NLM: 0155157
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
25
11
2020
revised:
15
12
2020
accepted:
20
12
2020
pubmed:
10
1
2021
medline:
29
7
2021
entrez:
9
1
2021
Statut:
ppublish
Résumé
Neonatal brachial plexus injury (NBPI) causes disabling and incurable muscle contractures that are driven by impaired growth of denervated muscles. A rare form of NBPI, which maintains afferent muscle innervation despite motor denervation, does not cause contractures. As afferent innervation regulates various aspects of skeletal muscle homeostasis through NRG/ErbB signaling, our current study investigated the role of this pathway in modulating contracture development. Through pharmacologic modification with an ErbB antagonist and NRG1 isoforms, we discovered that NRG/ErbB signaling does not modulate the development of contractures in neonatal mice. Instead, ErbB inhibition impeded growth in nondenervated skeletal muscles, whereas increased ErbB activation exacerbated denervation-induced skeletal muscle atrophy. This potential regulatory effect of NRG/ErbB signaling on neonatal muscle growth warrants deeper investigation.
Identifiants
pubmed: 33421114
doi: 10.1002/1873-3468.14034
pmc: PMC7940581
mid: NIHMS1661595
doi:
Substances chimiques
Morpholines
0
Neuregulin-1
0
Nrg1 protein, mouse
0
Canertinib
C78W1K5ASF
EGFR protein, mouse
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
655-666Subventions
Organisme : NICHD NIH HHS
ID : R01 HD098280
Pays : United States
Informations de copyright
© 2021 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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