Gut mycobiome: The probable determinative role of fungi in IBD patients.
Crohn's disease
Dysbiosis
Gut microbiota
Mycobiome
inflammatory bowel diseases
ulcerative colitis
Journal
Mycoses
ISSN: 1439-0507
Titre abrégé: Mycoses
Pays: Germany
ID NLM: 8805008
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
15
12
2020
received:
23
06
2020
accepted:
04
01
2021
pubmed:
10
1
2021
medline:
22
9
2021
entrez:
9
1
2021
Statut:
ppublish
Résumé
Inflammatory bowel disease (IBD) is a multi-factorial autoimmune disorder that its causative agents are unknown. The gut microbiota comprises of bacteria, viruses, fungi and protozoa that its role in IBD has remained controversially. Bacteria constitute more than 99% of the gut microbiota composition, and the main core of the gut microbiota is composed from Bacteroidetes and Firmicutes. The gut microbiota plays an important role in training, development and haemostasis of the immune responses during the life. Fungi compose a very small portion of gut microbiota, but play determinative roles in homeostasis of the gut bacterial composition and the mucosal immune responses. An interkingdom correlation between bacteria and fungi has been suggested. For example, the presence of Salmonella enterica serovar Typhimurium reduces the viability and colonisation of C albicans. Alterations in the composition and function of the gut microbiota, which is known as dysbiosis, are a usual event in patients who suffer from IBD. Although the main reason for this alteration is not clear, the interaction between gut bacteria and gut fungi seems to be an important subject in IBD patients. This review covers new findings on the interaction between fungi and bacteria and the role of fungi in the pathophysiology of IBD.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
468-476Informations de copyright
© 2021 Wiley-VCH GmbH.
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