Longitudinal associations between ambient air pollution and insulin sensitivity: results from the KORA cohort study.
Adult
Aged
Air Pollution
/ adverse effects
Biomarkers
/ blood
Blood Glucose
/ analysis
Cohort Studies
Diabetes Mellitus, Type 2
/ epidemiology
Environmental Exposure
/ adverse effects
Female
Germany
/ epidemiology
Humans
Insulin
/ blood
Insulin Resistance
Longitudinal Studies
Male
Middle Aged
Nitrogen Dioxide
/ analysis
Ozone
/ analysis
Particulate Matter
/ adverse effects
Surveys and Questionnaires
Journal
The Lancet. Planetary health
ISSN: 2542-5196
Titre abrégé: Lancet Planet Health
Pays: Netherlands
ID NLM: 101704339
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
24
07
2020
revised:
05
11
2020
accepted:
12
11
2020
entrez:
9
1
2021
pubmed:
10
1
2021
medline:
17
6
2021
Statut:
ppublish
Résumé
Impaired insulin sensitivity could be an intermediate step that links exposure to air pollution to the development of type 2 diabetes. However, longitudinal associations of air pollution with insulin sensitivity remain unclear. Our study investigated the associations of long-term air pollution exposure with the degree and rate of change of insulin sensitivity. In this longitudinal study, we analysed data from the Cooperative Health Research in the Region of Augsburg (KORA) cohort from Augsburg, Germany, which recruited participants aged 25-74 years in the survey between 1999 and 2001 (KORA S4), with two follow-up examinations in 2006-08 (KORA F4) and 2013-14 (KORA FF4). Serum concentrations of fasting insulin and glucose, and homoeostasis model assessment of insulin resistance (HOMA-IR, a surrogate measure of insulin sensitivity) and β-cell function (HOMA-B, a surrogate marker for fasting insulin secretion) were assessed at up to three visits between 1999 and 2014. Annual average air pollutant concentrations at the residence were estimated by land-use regression models. We examined the associations of air pollution with repeatedly assessed biomarker levels using mixed-effects models, and we assessed the associations with the annual rate of change in biomarkers using quantile regression models. Among 9620 observations from 4261 participants in the KORA cohort, we included 6008 (62·5%) observations from 3297 (77·4%) participants in our analyses. Per IQR increment in annual average air pollutant concentrations, HOMA-IR significantly increased by 2·5% (95% CI 0·3 to 4·7) for coarse particulate matter, by 3·1% (0·9 to 5·3) for PM Our study indicates that long-term air pollution exposure could contribute to the development of insulin resistance, which is one of the key factors in the pathogenesis of type 2 diabetes. German Federal Ministry of Education and Research.
Sections du résumé
BACKGROUND
Impaired insulin sensitivity could be an intermediate step that links exposure to air pollution to the development of type 2 diabetes. However, longitudinal associations of air pollution with insulin sensitivity remain unclear. Our study investigated the associations of long-term air pollution exposure with the degree and rate of change of insulin sensitivity.
METHODS
In this longitudinal study, we analysed data from the Cooperative Health Research in the Region of Augsburg (KORA) cohort from Augsburg, Germany, which recruited participants aged 25-74 years in the survey between 1999 and 2001 (KORA S4), with two follow-up examinations in 2006-08 (KORA F4) and 2013-14 (KORA FF4). Serum concentrations of fasting insulin and glucose, and homoeostasis model assessment of insulin resistance (HOMA-IR, a surrogate measure of insulin sensitivity) and β-cell function (HOMA-B, a surrogate marker for fasting insulin secretion) were assessed at up to three visits between 1999 and 2014. Annual average air pollutant concentrations at the residence were estimated by land-use regression models. We examined the associations of air pollution with repeatedly assessed biomarker levels using mixed-effects models, and we assessed the associations with the annual rate of change in biomarkers using quantile regression models.
FINDINGS
Among 9620 observations from 4261 participants in the KORA cohort, we included 6008 (62·5%) observations from 3297 (77·4%) participants in our analyses. Per IQR increment in annual average air pollutant concentrations, HOMA-IR significantly increased by 2·5% (95% CI 0·3 to 4·7) for coarse particulate matter, by 3·1% (0·9 to 5·3) for PM
INTERPRETATION
Our study indicates that long-term air pollution exposure could contribute to the development of insulin resistance, which is one of the key factors in the pathogenesis of type 2 diabetes.
FUNDING
German Federal Ministry of Education and Research.
Identifiants
pubmed: 33421408
pii: S2542-5196(20)30275-8
doi: 10.1016/S2542-5196(20)30275-8
pii:
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Insulin
0
Particulate Matter
0
Ozone
66H7ZZK23N
Nitrogen Dioxide
S7G510RUBH
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e39-e49Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.