Perinatal and early-life cobalt exposure impairs essential metal metabolism in immature ICR mice.

Aging Animals Animals, Newborn Body Weight / drug effects Cobalt / pharmacokinetics Female Kidney / drug effects Liver / drug effects Metals / metabolism Mice Mice, Inbred ICR Muscle, Skeletal / drug effects Organ Size / drug effects Pregnancy Prenatal Exposure Delayed Effects Spleen / drug effects
Cobalt Copper Hepcidin Iron Toxicity

Journal

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483

Informations de publication

Date de publication:
Mar 2021
Historique:
received: 01 07 2020
revised: 30 12 2020
accepted: 03 01 2021
pubmed: 10 1 2021
medline: 7 7 2021
entrez: 9 1 2021
Statut: ppublish

Résumé

The objective of the present study was to assess the impact of cobalt (Co) exposure on tissue distribution of iron (Fe), copper (Cu), manganese (Mn), and zinc (Zn), as well as serum hepcidin levels in immature mice (18, 25, 30 days). Pregnant mice were exposed to 75 mg/kg b.w. cobalt chloride (CoCl

Identifiants

DOI: 10.1016/j.fct.2021.111973 PMID: 33421458
pubmed: 33421458
pii: S0278-6915(21)00007-7
doi: 10.1016/j.fct.2021.111973
pii:
doi:

Substances chimiques

Metals 0
Cobalt 3G0H8C9362
cobaltous chloride EVS87XF13W

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111973

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Anatoly V Skalny (AV)

Yaroslavl State University, Yaroslavl, Russia; IM Sechenov First Moscow State Medical University, Moscow, 119146, Russia; KG Razumovsky Moscow State University of Technologies and Management, Moscow, Russia.

Yordanka Gluhcheva (Y)

Institute of Experimental Morphology, Pathology and Anthropology with Museum - Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria.

Olga P Ajsuvakova (OP)

Federal Research Centre of Biological Systems and Agro-technologies of the Russian Academy of Sciences, Orenburg, 460000, Russia.

Ekaterina Pavlova (E)

Institute of Experimental Morphology, Pathology and Anthropology with Museum - Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria.

Emilia Petrova (E)

Institute of Experimental Morphology, Pathology and Anthropology with Museum - Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria.

Pavel Rashev (P)

Institute of Biology and Immunology of Reproduction "Acad. Kiril Bratanov" - Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria.

Ivelin Vladov (I)

Institute of Experimental Morphology, Pathology and Anthropology with Museum - Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria.

Roza A Shakieva (RA)

Kazakh Academy of Nutrition, Almaty, Kazakhstan.

Michael Aschner (M)

IM Sechenov First Moscow State Medical University, Moscow, 119146, Russia; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.

Alexey A Tinkov (AA)

Yaroslavl State University, Yaroslavl, Russia; IM Sechenov First Moscow State Medical University, Moscow, 119146, Russia. Electronic address: tinkov.a.a@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Eucaryotes › Animaux › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cobalt › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Système digestif › Foie › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée ICR › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Taille d'organe › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Lésions prénatales › Effets différés de l'exposition prénatale à des facteurs de risque › Perinatal and early-life cobalt exposure...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Rate › Perinatal and early-life cobalt exposure...