When your brain looks older than expected: combined lifestyle risk and BrainAGE.
Lifestyle
MR-based age estimation
MR-morphometry
Physical activity
Smoking
Journal
Brain structure & function
ISSN: 1863-2661
Titre abrégé: Brain Struct Funct
Pays: Germany
ID NLM: 101282001
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
14
05
2020
accepted:
24
11
2020
pubmed:
11
1
2021
medline:
3
11
2021
entrez:
10
1
2021
Statut:
ppublish
Résumé
Lifestyle may be one source of unexplained variance in the great interindividual variability of the brain in age-related structural differences. While physical and social activity may protect against structural decline, other lifestyle behaviors may be accelerating factors. We examined whether riskier lifestyle correlates with accelerated brain aging using the BrainAGE score in 622 older adults from the 1000BRAINS cohort. Lifestyle was measured using a combined lifestyle risk score, composed of risk (smoking, alcohol intake) and protective variables (social integration and physical activity). We estimated individual BrainAGE from T1-weighted MRI data indicating accelerated brain atrophy by higher values. Then, the effect of combined lifestyle risk and individual lifestyle variables was regressed against BrainAGE. One unit increase in combined lifestyle risk predicted 5.04 months of additional BrainAGE. This prediction was driven by smoking (0.6 additional months of BrainAGE per pack-year) and physical activity (0.55 less months in BrainAGE per metabolic equivalent). Stratification by sex revealed a stronger association between physical activity and BrainAGE in males than females. Overall, our observations may be helpful with regard to lifestyle-related tailored prevention measures that slow changes in brain structure in older adults.
Identifiants
pubmed: 33423086
doi: 10.1007/s00429-020-02184-6
pii: 10.1007/s00429-020-02184-6
pmc: PMC7981332
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
621-645Subventions
Organisme : Horizon 2020 Framework Programme
ID : 785907
Organisme : Horizon 2020 Framework Programme
ID : 945539
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