IRF5 regulates airway macrophage metabolic responses.
Animals
Cells, Cultured
Chromatin Immunoprecipitation Sequencing
/ methods
Energy Metabolism
/ genetics
Female
Gene Expression Regulation
/ immunology
Hexokinase
/ genetics
Humans
Interferon Regulatory Factors
/ genetics
Macrophages
/ immunology
Mice, Inbred C57BL
Mice, Knockout
Respiratory System
/ cytology
Sirtuins
/ genetics
Toll-Like Receptor 3
/ genetics
lung
macrophage
metabolism
transcription factors
virus
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
04
10
2020
revised:
13
12
2020
accepted:
16
12
2020
pubmed:
11
1
2021
medline:
28
9
2021
entrez:
10
1
2021
Statut:
ppublish
Résumé
Interferon regulatory factor 5 (IRF5) is a master regulator of macrophage phenotype and a key transcription factor involved in expression of proinflammatory cytokine responses to microbial and viral infection. Here, we show that IRF5 controls cellular and metabolic responses. By integrating ChIP sequencing (ChIP-Seq) and assay for transposase-accessible chromatin using sequencing (ATAC)-seq data sets, we found that IRF5 directly regulates metabolic genes such as hexokinase-2 (Hk2). The interaction of IRF5 and metabolic genes had a functional consequence, as Irf5
Identifiants
pubmed: 33423291
doi: 10.1111/cei.13573
pmc: PMC7944363
doi:
Substances chimiques
Interferon Regulatory Factors
0
Toll-Like Receptor 3
0
Sirt6 protein, mouse
EC 2.4.2.31
Hexokinase
EC 2.7.1.1
hexokinase 2, mouse
EC 2.7.1.1
Sirtuins
EC 3.5.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
134-143Subventions
Organisme : Wellcome Trust
ID : 209422/Z/17/Z
Pays : United Kingdom
Organisme : Asthma UK
ID : AUK-SNF-2017- 381
Organisme : Wellcome
ID : 107059/Z/15/Z
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100156/Z/12/Z
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Clinical & Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology.
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