Metabolomics Insights in Early Childhood Caries.

Child Child, Preschool Cross-Sectional Studies Dental Caries / diagnosis Dental Caries Susceptibility Humans Metabolomics North Carolina / epidemiology Prevalence
biofilm children dental caries machine learning microbiome risk assessment

Journal

Journal of dental research
ISSN: 1544-0591
Titre abrégé: J Dent Res
Pays: United States
ID NLM: 0354343

Informations de publication

Date de publication:
06 2021
Historique:
pubmed: 12 1 2021
medline: 10 7 2021
entrez: 11 1 2021
Statut: ppublish

Résumé

Dental caries is characterized by a dysbiotic shift at the biofilm-tooth surface interface, yet comprehensive biochemical characterizations of the biofilm are scant. We used metabolomics to identify biochemical features of the supragingival biofilm associated with early childhood caries (ECC) prevalence and severity. The study's analytical sample comprised 289 children ages 3 to 5 (51% with ECC) who attended public preschools in North Carolina and were enrolled in a community-based cross-sectional study of early childhood oral health. Clinical examinations were conducted by calibrated examiners in community locations using International Caries Detection and Classification System (ICDAS) criteria. Supragingival plaque collected from the facial/buccal surfaces of all primary teeth in the upper-left quadrant was analyzed using ultra-performance liquid chromatography-tandem mass spectrometry. Associations between individual metabolites and 18 clinical traits (based on different ECC definitions and sets of tooth surfaces) were quantified using Brownian distance correlations (dCor) and linear regression modeling of log

Identifiants

DOI: 10.1177/0022034520982963 PMID: 33423574 PMC: PMC8142089
pubmed: 33423574
doi: 10.1177/0022034520982963
pmc: PMC8142089
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

615-622

Subventions

Organisme : NIDCR NIH HHS
ID : R01 DE025220
Pays : United States
Organisme : NIDCR NIH HHS
ID : R03 DE028983
Pays : United States
Organisme : NIDCR NIH HHS
ID : U01 DE025046
Pays : United States

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Auteurs

L H Heimisdottir (LH)

Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
ORCID: 0000-0002-7630-8883

B M Lin (BM)

Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.

H Cho (H)

Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.

A Orlenko (A)

Department of Biostatistics, Epidemiology and Informatics, Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA.

A A Ribeiro (AA)

Division of Diagnostic Sciences, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.

A Simon-Soro (A)

Biofilm Research Labs, Center for Innovation and Precision Dentistry, School of Dental Medicine and School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Stomatology, School of Dentistry, University of Sevilla, Sevilla, Spain.

J Roach (J)

Research Computing, University of North Carolina, Chapel Hill, NC, USA.

D Shungin (D)

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Department of Odontology, Umeå University, Umeå, Sweden.

J Ginnis (J)

Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.

M A Simancas-Pallares (MA)

Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.

H D Spangler (HD)

Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.

A G Ferreira Zandoná (AGF)

Department of Comprehensive Care, School of Dental Medicine, Tufts University, Boston, MA, USA.

J T Wright (JT)

Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.

P Ramamoorthy (P)

Metabolon, Inc., Durham, NC, USA.

J H Moore (JH)

Department of Biostatistics, Epidemiology and Informatics, Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, PA, USA.

H Koo (H)

Biofilm Research Labs, Center for Innovation and Precision Dentistry, School of Dental Medicine and School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.
Department of Orthodontics and Divisions of Pediatric Dentistry and Community Oral Health, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA.

D Wu (D)

Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
Division of Oral & Craniofacial Health Sciences, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.

K Divaris (K)

Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.
Department of Epidemiology, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA.
ORCID: 0000-0003-1290-7251

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Metabolomics Insights in Early Childhood Caries.
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Metabolomics Insights in Early Childhood Caries.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Metabolomics Insights in Early Childhood Caries.
questionsmedicales.fr › Maladies du système stomatognathique › Maladies des dents › Déminéralisation dentaire › Caries dentaires › Metabolomics Insights in Early Childhood Caries.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques dentaires › Susceptibilité à la carie dentaire › Metabolomics Insights in Early Childhood Caries.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolomics Insights in Early Childhood Caries.
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Metabolomics Insights in Early Childhood Caries.
questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Nord › États-Unis › États du Sud-Est des États-Unis › Caroline du Nord › Metabolomics Insights in Early Childhood Caries.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Metabolomics Insights in Early Childhood Caries.