The role of microglia membrane potential in chemotaxis.
Calcium signaling
Channelrhodopsin
Chemotaxis
Hippocampus
Laser damage
Microglia
Optogenetics
Sterile inflammation
Two-photon microscopy
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
10 Jan 2021
10 Jan 2021
Historique:
received:
09
10
2020
accepted:
09
12
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
8
9
2021
Statut:
epublish
Résumé
Microglia react to danger signals by rapid and targeted extension of cellular processes towards the source of the signal. This positive chemotactic response is accompanied by a hyperpolarization of the microglia membrane. Here, we show that optogenetic depolarization of microglia has little effect on baseline motility, but significantly slows down the chemotactic response. Reducing the extracellular Ca
Identifiants
pubmed: 33423699
doi: 10.1186/s12974-020-02048-0
pii: 10.1186/s12974-020-02048-0
pmc: PMC7798195
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 278170285
Organisme : Deutsche Forschungsgemeinschaft
ID : 220176618
Organisme : Deutsche Forschungsgemeinschaft
ID : 178316478
Commentaires et corrections
Type : ErratumIn
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