Role of Astrocytic Inwardly Rectifying Potassium (Kir) 4.1 Channels in Epileptogenesis.
BDNF
Kir4.1 channels
astrocytes
epilepsy
glutamate
spatial potassium buffering
tripartite synapse
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
11
2020
accepted:
08
12
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
Astrocytes regulate potassium and glutamate homeostasis via inwardly rectifying potassium (Kir) 4.1 channels in synapses, maintaining normal neural excitability. Numerous studies have shown that dysfunction of astrocytic Kir4.1 channels is involved in epileptogenesis in humans and animal models of epilepsy. Specifically, Kir4.1 channel inhibition by
Identifiants
pubmed: 33424762
doi: 10.3389/fneur.2020.626658
pmc: PMC7786246
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
626658Informations de copyright
Copyright © 2020 Kinboshi, Ikeda and Ohno.
Déclaration de conflit d'intérêts
AI and MK belong to Department of Epilepsy, Movement Disorders and Physiology at Kyoto University is Industry-Academia Collaboration Courses, supported by Eisai Co., Ltd., Nihon Kohden Corporation, Otsuka Pharmaceutical Co., and UCB Japan Co., Ltd. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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