Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism.
Journal
International journal of endocrinology
ISSN: 1687-8337
Titre abrégé: Int J Endocrinol
Pays: Egypt
ID NLM: 101516376
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
06
2020
revised:
30
10
2020
accepted:
06
12
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
Evidence suggests that vitamin D deficiency correlated with metabolic disorders in women with polycystic ovary syndrome (PCOS). We conducted this systematic review and meta-analysis to evaluate the impact of vitamin D supplementation alone on glucose, lipid, and androgen parameters and inflammation biomarkers in women with PCOS. Literature research was conducted in Pubmed, Embase, Web of Science, Clinical Trials, and Cochrane Library to identify relevant randomized controlled trials (RCTs) up to March 2020. The effect of vitamin D supplementation alone on women with PCOS was compared with administration of placebo. The systematic review and meta-analysis protocol was registered in the International Prospective Register of Systematic Reviews (Prospero) as number CRD42020157444. Thirteen randomized controlled trials with 824 patients in total were included. Serum FPG, fasting insulin, HOMA-IR, and VLDL-C were significantly decreased in the vitamin D group versus placebo. Vitamin D supplementation group also showed a significantly elevated level of QUICKI. No significant impact was seen on serum triglyceride, total-C, LDL-C, HDL-C, total testosterone, DHEAS, SHBG, or hs-CRP. Subgroup analysis demonstrated that oral vitamin D intake had significantly decreased serum triglyceride and total-C level in women with PCOS who have vitamin D deficiency (serum vitamin The findings of the present meta-analysis indicate that vitamin D supplementation exerted favorable effects among women with PCOS on glucose metabolism and lipid metabolism, especially in vitamin D deficient women, but had no significant effect on the androgenic profile or inflammation status.
Identifiants
pubmed: 33424968
doi: 10.1155/2020/7850816
pmc: PMC7773476
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7850816Informations de copyright
Copyright © 2020 Shan Guo et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest related to this work.
Références
Nutrients. 2019 Jan 17;11(1):
pubmed: 30658483
Cardiovasc Res. 1997 May;34(2):404-10
pubmed: 9205555
Eur J Nutr. 2019 Aug;58(5):2019-2028
pubmed: 29946756
Hum Reprod. 2012 Oct;27(10):3015-27
pubmed: 22824625
Horm Metab Res. 2017 Jul;49(7):493-498
pubmed: 28679140
Horm Metab Res. 2017 Mar;49(3):174-179
pubmed: 28351084
Clin Endocrinol (Oxf). 2015 Dec;83(6):888-94
pubmed: 26119844
Complement Ther Clin Pract. 2017 Feb;26:53-60
pubmed: 28107851
PLoS One. 2018 Dec 4;13(12):e0204748
pubmed: 30513089
Nutrients. 2017 Mar 28;9(4):
pubmed: 28350328
J Endocrinol Invest. 2013 Jan;36(1):28-32
pubmed: 22453059
Eur J Endocrinol. 2012 May;166(5):765-78
pubmed: 22275473
Iran J Reprod Med. 2012 Sep;10(5):465-72
pubmed: 25246913
Diabetes Care. 1996 Oct;19(10):1113-7
pubmed: 8886558
Cell. 2018 May 17;173(5):1135-1149.e15
pubmed: 29754817
Ann Intern Med. 2009 Aug 18;151(4):264-9, W64
pubmed: 19622511
J Steroid Biochem Mol Biol. 2019 Jan;185:17-26
pubmed: 30071248
Nutr Res. 2011 Jan;31(1):48-54
pubmed: 21310306
Nutrients. 2018 Nov 02;10(11):
pubmed: 30400199
J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30
pubmed: 21646368
Int J Clin Pract. 2017 Jun;71(6):
pubmed: 28524342
J Clin Endocrinol Metab. 2003 Nov;88(11):5321-6
pubmed: 14602768
J Obstet Gynaecol India. 2017 Oct;67(5):349-355
pubmed: 28867886
Arch Gynecol Obstet. 2017 Feb;295(2):487-496
pubmed: 27933387
J Endocrinol Invest. 2018 May;41(5):597-607
pubmed: 29110281
Gynecol Endocrinol. 2018 Jun;34(6):489-494
pubmed: 29271278
Nutr Res. 2012 Mar;32(3):195-201
pubmed: 22464806
Matern Child Nutr. 2017 Jul;13(3):
pubmed: 27612307
J Clin Endocrinol Metab. 2015 Nov;100(11):4307-14
pubmed: 26485217
Cochrane Database Syst Rev. 2018 Jul 24;7:CD010564
pubmed: 30039871
Fertil Steril. 2014 Aug;102(2):460-468.e3
pubmed: 24933120
Semin Reprod Med. 2015 May;33(3):195-207
pubmed: 26036901
Endocr Rev. 1997 Dec;18(6):774-800
pubmed: 9408743
Fertil Steril. 2006 Mar;85(3):679-88
pubmed: 16500338
Horm Metab Res. 2018 Apr;50(4):271-279
pubmed: 29475212
Clin Nutr. 2015 Aug;34(4):586-92
pubmed: 25300649
Womens Health (Lond). 2015 Jul;11(4):501-12
pubmed: 25756387
Rev Obstet Gynecol. 2009 Fall;2(4):232-9
pubmed: 20111659