A Simple Cardiovascular Model for the Study of Hemorrhagic Shock.
Journal
Computational and mathematical methods in medicine
ISSN: 1748-6718
Titre abrégé: Comput Math Methods Med
Pays: United States
ID NLM: 101277751
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
06
2020
revised:
08
09
2020
accepted:
25
11
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
28
8
2021
Statut:
epublish
Résumé
Hemorrhagic shock is the number one cause of death on the battlefield and in civilian trauma as well. Mathematical modeling has been applied in this context for decades; however, the formulation of a satisfactory model that is both practical and effective has yet to be achieved. This paper introduces an upgraded version of the 2007 Zenker model for hemorrhagic shock termed the ZenCur model that allows for a better description of the time course of relevant observations. Our study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock. This model is capable of replicating the changes in mean arterial pressure, heart rate, and cardiac output after the onset of bleeding (as observed in four experimental laboratory animals) and achieves a reasonable compromise between an overly detailed depiction of relevant mechanisms, on the one hand, and model simplicity, on the other. The former would require considerable simulations and entail burdensome interpretations. From a clinical standpoint, the goals of the new model are to predict survival and optimize the timing of therapy, in both civilian and military scenarios.
Identifiants
pubmed: 33425003
doi: 10.1155/2020/7936895
pmc: PMC7781723
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7936895Informations de copyright
Copyright © 2020 Luciano Curcio et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest in this paper.
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