Time Course of Changes in Serum Oxidative Stress Markers to Predict Outcomes for Surgical Treatment of Lumbar Degenerative Disorders.
Adult
Aged
Aged, 80 and over
Biomarkers
/ blood
Bone Density
Female
Follow-Up Studies
Humans
Intervertebral Disc Degeneration
/ blood
Lumbar Vertebrae
/ surgery
Male
Middle Aged
Nervous System Diseases
/ complications
Oxidative Stress
Reactive Oxygen Species
Time Factors
Treatment Outcome
Visual Analog Scale
Young Adult
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
03
2020
revised:
05
10
2020
accepted:
12
12
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
14
9
2021
Statut:
epublish
Résumé
Recent reports indicate that oxidative stress is involved in the pathobiology of acute spinal cord injury or compression myelopathy. We conducted an observational study to determine levels of oxidative stress markers in serum from 80 patients who underwent spinal surgery to treat neurological symptoms related to lumbar degenerative disorders. Serum samples were collected before surgery and at 3 months, 6 months, and 1 year after surgery. Derivatives of reactive oxygen metabolites (ROM) in the serum samples were measured to gauge the level of oxidative stress. For preoperative neurological evaluation, patients were assessed for motor weakness in the lower extremities. We divided the patient samples into two groups: ROM decreasing at 1 year after surgery (G group) and ROM increasing at 1 year after surgery (W group). Then, we evaluated clinical outcomes using the visual analog scale and Oswestry disability index (ODI). Among the samples from the 80 enrolled patients, mean ROM levels before surgery increased to 388.5 ± 92.0, indicating the presence of moderate oxidative stress. The level of ROM gradually decreased after surgery and 1 year after surgery: the levels had significantly decreased to 367.6 ± 83.3 (
Identifiants
pubmed: 33425210
doi: 10.1155/2020/5649767
pmc: PMC7775168
doi:
Substances chimiques
Biomarkers
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5649767Informations de copyright
Copyright © 2020 Hiroshi Takahashi et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest in relation to this research and its publication.
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