The effect of bone marrow-derived stem cells associated with platelet-rich plasma on the osseointegration of immediately placed implants.
Journal
Journal of clinical and experimental dentistry
ISSN: 1989-5488
Titre abrégé: J Clin Exp Dent
Pays: Spain
ID NLM: 101603132
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
02
01
2020
accepted:
14
05
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
Stem cells associated with growth factors have been shown to improve bone healing and the osseointegration of dental implants. A Brazilian miniature pig model was used to evaluate the effect of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) associated with platelet-rich plasma (PRP) on the osseointegration of immediately placed dental implants. A total of four male adult miniature pigs were used in this study. BM-MSCs from each pig were isolated from the iliac crest and expanded The ILR, the BIC, and the BDWT for the control and experimental sites were respectively 25.0% and 18.7% ( The use of BM-MSCs + PRP in conjunction with immediately placed implants showed a lower ILR but there was no significant effect on the osseointegration of the dental implants. More preclinical studies, in large animal models, are needed to establish whether BM-MSCs associated with PRP could be used for the enhancement of the osseointegration of dental implants.
Sections du résumé
BACKGROUND
BACKGROUND
Stem cells associated with growth factors have been shown to improve bone healing and the osseointegration of dental implants. A Brazilian miniature pig model was used to evaluate the effect of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) associated with platelet-rich plasma (PRP) on the osseointegration of immediately placed dental implants.
MATERIAL AND METHODS
METHODS
A total of four male adult miniature pigs were used in this study. BM-MSCs from each pig were isolated from the iliac crest and expanded
RESULTS
RESULTS
The ILR, the BIC, and the BDWT for the control and experimental sites were respectively 25.0% and 18.7% (
CONCLUSIONS
CONCLUSIONS
The use of BM-MSCs + PRP in conjunction with immediately placed implants showed a lower ILR but there was no significant effect on the osseointegration of the dental implants. More preclinical studies, in large animal models, are needed to establish whether BM-MSCs associated with PRP could be used for the enhancement of the osseointegration of dental implants.
Identifiants
pubmed: 33425225
doi: 10.4317/jced.56743
pii: 56743
pmc: PMC7781218
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e8-e13Informations de copyright
Copyright: © 2021 Medicina Oral S.L.
Déclaration de conflit d'intérêts
Conflicts of interest None declared.
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