Combination of platelet-rich plasma and stromal vascular fraction on the level of transforming growth factor-β in rat subjects experiencing deep dermal burn injury.
Burn injury
Experimental research
Platelet-rich plasma
Stromal vascular fraction
TGF-β
Journal
Annals of medicine and surgery (2012)
ISSN: 2049-0801
Titre abrégé: Ann Med Surg (Lond)
Pays: England
ID NLM: 101616869
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
12
11
2020
revised:
28
11
2020
accepted:
29
11
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
The combination of stromal vascular fraction (SVF) and platelet-rich plasma (PRP) is effective at increasing the concentration of growth factors including transforming growth factor-β (TGF-β). The increase in this growth factor is expected to accelerate the healing of burns. This study aims to determine the effect of giving a combination of SVFs and PRP on TGF-β levels in the healing process of deep dermal burns. This was an experimental study in 64 rats using a post-test control group design consisting of 1 group of SVFs and PRP combination injection treatment group, 1 group given a topical combination of SVFs and PRP, 1 group given Vaseline, and 1 control group. There was a significant difference in TGF-β levels between the deep dermal burns group that was given a combination of SVFs and PRP injection and topical, the Vaseline group, and the control group with p-value <0.05. The combination of SVFs and PRP increases the level of TGF-β in the healing process of deep dermal burns.
Identifiants
pubmed: 33425344
doi: 10.1016/j.amsu.2020.11.088
pii: S2049-0801(20)30515-X
pmc: PMC7779951
doi:
Types de publication
Journal Article
Langues
eng
Pagination
737-742Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interests.
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