Pro-inflammatory dopamine-2 receptor-specific T cells in paediatric movement and psychiatric disorders.
autoimmune encephalitis
autoimmunity
dopamine‐2 receptor antibodies
neurodevelopmental disorders
pro‐inflammatory T cells
Journal
Clinical & translational immunology
ISSN: 2050-0068
Titre abrégé: Clin Transl Immunology
Pays: Australia
ID NLM: 101638268
Informations de publication
Date de publication:
2020
2020
Historique:
received:
17
09
2020
revised:
09
11
2020
revised:
29
11
2020
accepted:
29
11
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
A dysregulated inflammatory response against the dopamine-2 receptor (D2R) has been implicated in movement and psychiatric disorders. D2R antibodies were previously reported in a subset of these patients; however, the role of T cells in these disorders remains unknown. Our objective was to identify and characterise pro-inflammatory D2R-specific T cells in movement and psychiatric disorders. Blood from paediatric patients with movement and psychiatric disorders of suspected autoimmune and neurodevelopmental aetiology ( Three immunodominant regions of D2R, amino acid (aa)121-131, aa171-181 and aa396-416, specifically activated CD4 Autoreactive D2R-specific T cells and a pro-inflammatory Th1 and Th17 cytokine profile characterise a subset of paediatric patients with movement and psychiatric disorders, further underpinning the theory of immune dysregulation in these disorders. These findings offer new perspectives into the neuroinflammatory mechanisms of movement and psychiatric disorders and can influence patient diagnosis and treatment.
Identifiants
pubmed: 33425355
doi: 10.1002/cti2.1229
pii: CTI21229
pmc: PMC7780098
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e1229Informations de copyright
© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology Inc.
Déclaration de conflit d'intérêts
DP reports funding from the Neville Brown Scholarship (Australia). SR reports fellowship research funding from the National Health and Medical Research Council (Australia). RCD and FB have received research funding from the Trish Multiple Sclerosis Research Foundation, Multiple Sclerosis Research Australia, the Petre Foundation and the National Health Medical Research Council (Australia). They have received honoraria from Biogen Idec and Merck Serono as invited speakers. AZ, RD, JAL, FT, GL, FXZL, VM, SDH, AP, HFJ, SM, ADK and SIA declare no competing interests.
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