Cancer Omics in Africa: Present and Prospects.
African continent
cancer genomics
epigenomics
metabolomics
metagenomics
multi omics
proteomics
transcriptomics
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
09
2020
accepted:
11
11
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
During the last century, cancer biology has been arguably one of the most investigated research fields. To gain deeper insight into cancer mechanisms, scientists have been attempting to integrate multi omics data in cancer research. Cancer genomics, transcriptomics, metabolomics, proteomics, and metagenomics are the main multi omics strategies used currently in the diagnosis, prognosis, treatment, and biomarker discovery in cancer. In this review, we describe the use of different multi omics strategies in cancer research in the African continent and discuss the main challenges facing the implementation of these approaches in African countries such as the lack of training programs in bioinformatics in general and omics strategies in particular and suggest paths to address deficiencies. As a way forward, we advocate for the establishment of an "African Cancer Genomics Consortium" to promote intracontinental collaborative projects and enhance engagement in research activities that address indigenous aspects for cancer precision medicine.
Identifiants
pubmed: 33425763
doi: 10.3389/fonc.2020.606428
pmc: PMC7793679
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
606428Informations de copyright
Copyright © 2020 El Jaddaoui, Allali, Sehli, Ouldim, Hamdi, Al Idrissi, Nejjari, Amzazi, Bakri and Ghazal.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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