Alkaline Phosphatases Account for Low Plasma Levels of Inorganic Pyrophosphate in Chronic Kidney Disease.
alkaline phosphatase activity
hemodialysis
kidney transplant
mineral and bone disorder (CKD-MBD)
purinergic mechanisms
pyrophosphate
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
07
2020
accepted:
16
11
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
Patients on dialysis and kidney transplant recipients (KTR) present the syndrome of mineral and bone disorders (MBD), which share common traits with monogenic calcifying diseases related to disturbances of the purinergic system. Low plasma levels of inorganic pyrophosphate (PP We included 10 controls, 10 patients on maintenance dialysis, 10 early KTR 3 ± 1 months after transplantation and nine late KTR 24 ± 3 months after transplantation. We measured aortic calcifications, plasma and urine levels of PP Low PP Patients on dialysis and KTR have low plasma levels of PP
Identifiants
pubmed: 33425894
doi: 10.3389/fcell.2020.586831
pmc: PMC7793922
doi:
Types de publication
Journal Article
Langues
eng
Pagination
586831Informations de copyright
Copyright © 2020 Laurain, Rubera, Duranton, Rutsch, Nitschke, Ray, Vido, Sicard, Lefthériotis and Favre.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past co-authorship with several of the authors FR, YN, and GL.
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