Caspase-2 Substrates: To Apoptosis, Cell Cycle Control, and Beyond.
BID
MDM2
PIDD
Raidd
apoptosis
caspase-2
cell cycle
tumor suppressor
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
09
2020
accepted:
03
12
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
Caspase-2 belongs to the caspase family of proteins responsible for essential cellular functions including apoptosis and inflammation. Uniquely, caspase-2 has been identified as a tumor suppressor, but how it regulates this function is still unknown. For many years, caspase-2 has been considered an "orphan" caspase because, although it is able to induce apoptosis, there is an abundance of conflicting evidence that questions its necessity for apoptosis. Recent evidence supports that caspase-2 has non-apoptotic functions in the cell cycle and protection from genomic instability. It is unclear how caspase-2 regulates these opposing functions, which has made the mechanism of tumor suppression by caspase-2 difficult to determine. As a protease, caspase-2 likely exerts its functions by proteolytic cleavage of cellular substrates. This review highlights the known substrates of caspase-2 with a special focus on their functional relevance to caspase-2's role as a tumor suppressor.
Identifiants
pubmed: 33425918
doi: 10.3389/fcell.2020.610022
pmc: PMC7785872
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
610022Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM121389
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA256606
Pays : United States
Informations de copyright
Copyright © 2020 Brown-Suedel and Bouchier-Hayes.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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