Purification and Functional Characterization of the Chloroform/Methanol-Soluble Protein 3 (CM3) From
ATIs
CM3
Drosophila melanogaster
non-celiac wheat sensitivity
α-glucosidase
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
09
2020
accepted:
30
11
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
Non-celiac wheat sensitivity (NCWS) has been proposed to be an independent disease entity that is characterized by intestinal (e.g., abdominal pain, flatulence) and extra-intestinal symptoms (e.g., headache, fatigue), which are propagated following the ingestion of wheat products. Increased activity of amylase trypsin inhibitors (ATIs) in modern wheat is suggested to be major trigger of NCWS, while underlying mechanisms still remain elusive. Here, we aimed to generate and functionally characterize the most abundant ATI in modern wheat, chloroform/methanol-soluble protein 3 (CM3),
Identifiants
pubmed: 33425975
doi: 10.3389/fnut.2020.607937
pmc: PMC7785803
doi:
Types de publication
Journal Article
Langues
eng
Pagination
607937Informations de copyright
Copyright © 2020 Thiel, Ragab, Wagner, Divanovic, Derer and Sina.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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