Metabolomic Signature of Human Aortic Valve Stenosis.
AS, aortic stenosis
ATX, autotaxin
AV, aortic valve
AVA, aortic valve area
BAV, bicuspid aortic valve
CAVS, calcific aortic valve stenosis
CV, correlation of variation
Lp(a), lipoprotein(a)
LysoPA, lysophosphatidic acid
LysoPC, lysophosphatidylcholine
LysoPE, lysophosphatidylethanolamine
MG, monoglyceride
MPG, mean pressure gradient
PC, phosphatidylcholine
QC, quality control
TAV, tricuspid aortic valve
Vmax, peak aortic jet velocity
aortic stenosis
calcific aortic valve stenosis
lysophosphatidic acids
nontargeted metabolomics
targeted lipidomics
valvular calcification
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
23
04
2020
revised:
01
10
2020
accepted:
01
10
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
This study outlines the first step toward creating the metabolite atlas of human calcified aortic valves by identifying the expression of metabolites and metabolic pathways involved at various stages of calcific aortic valve stenosis progression. Untargeted analysis identified 72 metabolites and lipids that were significantly altered (p < 0.01) across different stages of disease progression. Of these metabolites and lipids, the levels of lysophosphatidic acid were shown to correlate with faster hemodynamic progression and could select patients at risk for faster progression rate.
Identifiants
pubmed: 33426374
doi: 10.1016/j.jacbts.2020.10.001
pii: S2452-302X(20)30434-4
pmc: PMC7775961
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1163-1177Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
Dr. Ravandi is supported by a grant from Research Manitoba and Heart and Stroke Foundation of Canada. Mr. Surendran is supported by Research Manitoba Master’s Studentship (2018), Bank of Montreal/Institute of Cardiovascular Sciences Studentship (2019), and Singal, Pawan K. Graduate Scholarship in Cardiovascular Sciences (2019). All other have reported that they have no relationships relevant to the contents of this paper to disclose.
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