Treatment Targets for Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.
FAO, fatty acid oxidation
IPAH, idiopathic pulmonary arterial hypertension
LV, left ventricle/ventricular
PAH, pulmonary arterial hypertension
PH, pulmonary hypertension
RAAS, renin-angiotensin-aldosterone system
RV, right ventricle/ventricular
RVH, right ventricular hypertrophy
SSc-PAH, systemic sclerosis-associated pulmonary arterial hypertension
clinical trials
miRNA/miR, micro-ribonucleic acid
pulmonary arterial hypertension
right ventricle
Journal
JACC. Basic to translational science
ISSN: 2452-302X
Titre abrégé: JACC Basic Transl Sci
Pays: United States
ID NLM: 101677259
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
08
06
2020
revised:
27
07
2020
accepted:
27
07
2020
entrez:
11
1
2021
pubmed:
12
1
2021
medline:
12
1
2021
Statut:
epublish
Résumé
Right ventricle (RV) dysfunction is the strongest predictor of mortality in pulmonary arterial hypertension (PAH), but, at present, there are no therapies directly targeting the failing RV. Although there are shared molecular mechanisms in both RV and left ventricle (LV) dysfunction, there are important differences between the 2 ventricles that may allow for the development of RV-enhancing or RV-directed therapies. In this review, we discuss the current understandings of the dysregulated pathways that promote RV dysfunction, highlight RV-enriched or RV-specific pathways that may be of particular therapeutic value, and summarize recent and ongoing clinical trials that are investigating RV function in PAH. It is hoped that development of RV-targeted therapies will improve quality of life and enhance survival for this deadly disease.
Identifiants
pubmed: 33426379
doi: 10.1016/j.jacbts.2020.07.011
pii: S2452-302X(20)30345-4
pmc: PMC7775863
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1244-1260Subventions
Organisme : NHLBI NIH HHS
ID : K08 HL140100
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL144472
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002494
Pays : United States
Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
Dr. Prisco is funded by National Institutes of Health (NIH) grant T32 HL144472, a University of Minnesota Clinical and Translational Science award (NIH UL1 TR0029494), and a University of Minnesota Medical School Academic Investment Educational Program grant. Dr. Prins is funded by NIH K08 HL140100, the Jenesis Award from United Therapeutics, a Lillehei Heart Institute Cardiovascular Seed Grant, and the Cardiovascular Medical Research and Education Fund; and has served as a consultant for Actelion and receives grant funding from United Therapeutics. Dr. Thenappan has served as a consultant for Actelion and Gilead. The content of this article is solely the responsibility of the authors and does not represent the official views of the NIH or any other funding sources. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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