Low doses of uranium and osteoclastic bone resorption: key reciprocal effects evidenced using new in vitro biomimetic models of bone matrix.
Biomimetic models
Bone
Extracellular matrix
Osteoclasts
Resorption
Uranium
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
16
09
2020
accepted:
22
12
2020
pubmed:
12
1
2021
medline:
28
10
2021
entrez:
11
1
2021
Statut:
ppublish
Résumé
Uranium is widely spread in the environment due to its natural and anthropogenic occurrences, hence the importance of understanding its impact on human health. The skeleton is the main site of long-term accumulation of this actinide. However, interactions of this metal with biological processes involving the mineralized extracellular matrix and bone cells are still poorly understood. To get a better insight into these interactions, we developed new biomimetic bone matrices containing low doses of natural uranium (up to 0.85 µg of uranium per cm
Identifiants
pubmed: 33426622
doi: 10.1007/s00204-020-02966-1
pii: 10.1007/s00204-020-02966-1
doi:
Substances chimiques
Uranium
4OC371KSTK
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1023-1037Références
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