Treat-to-Target Approach for the Management of Patients with Moderate-to-Severe Plaque Psoriasis: Consensus Recommendations.
Consensus
Plaque psoriasis
Quality of life
Systemic inflammation
Treat-to-target
Journal
Dermatology and therapy
ISSN: 2193-8210
Titre abrégé: Dermatol Ther (Heidelb)
Pays: Switzerland
ID NLM: 101590450
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
05
11
2020
accepted:
02
12
2020
pubmed:
12
1
2021
medline:
12
1
2021
entrez:
11
1
2021
Statut:
ppublish
Résumé
Treat-to-target strategies are used in several chronic diseases to improve outcomes. Treatment goals have also been suggested for psoriasis, but there is currently no consensus on targets, and guidance is needed to implement this strategy in clinical practice. The project 'Treat to Target Italia' was launched by a scientific board (SB) of 10 psoriasis experts to generate expert consensus recommendations. On the basis of the published literature, their clinical experience, and the results of a survey among Italian dermatologists, the SB identified four relevant topics: (1) clinical remission; (2) quality of life; (3) abrogation of systemic inflammation; (4) safety. They drafted 20 statements addressing these four topics and submitted them to a panel of 28 dermatologists, in a Delphi process, to achieve consensus (greater than 80% agreement). Consensus was reached on all statements. Treatment goals defining clinical remission should include a 90% improvement from baseline in the Psoriasis Area and Severity Index (PASI90 response) or an absolute PASI score of less than or equal to 3. Patient's quality of life and satisfaction are important targets. If PASI targets are achieved, there should be no or very low impact of psoriasis on quality of life [Dermatology Life Quality Index (DLQI) score less than or equal to 3]. If PASI or DLQI goals are not achieved within 3-4 months, treatment should be changed. Abrogation of systemic inflammation may be crucial for preventing or delaying inflammatory comorbidities. Safety is an equally important target as efficacy. These 20 consensus statements define the parameters of a treat-to-target strategy for psoriasis in Italy. It is hoped that use of these in the management of patients with psoriasis will improve treatment outcomes and patient health-related quality of life.
Identifiants
pubmed: 33426634
doi: 10.1007/s13555-020-00475-8
pii: 10.1007/s13555-020-00475-8
pmc: PMC7859133
doi:
Types de publication
Journal Article
Langues
eng
Pagination
235-252Références
Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ. Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol. 2005;141(12):1537–41. https://doi.org/10.1001/archderm.141.12.1537 .
doi: 10.1001/archderm.141.12.1537
pubmed: 16365254
Parisi R, Symmons DP, Griffiths CE, Ashcroft DM, Identification and Management of Psoriasis and Associated Comorbidity (IMPACT) project team. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013;133(2):377–85. https://doi.org/10.1038/jid.2012.339 .
doi: 10.1038/jid.2012.339
pubmed: 23014338
Stern RS, Nijsten T, Feldman SR, Margolis DJ, Rolstad T. Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction. J Investig Dermatol Symp Proc. 2004;9(2):136–9. https://doi.org/10.1046/j.1087-0024.2003.09102.x .
doi: 10.1046/j.1087-0024.2003.09102.x
pubmed: 15083780
Reich K. The concept of psoriasis as a systemic inflammation: implications for disease management. J Eur Acad Dermatol Venereol. 2012;26(Suppl 2):3–11. https://doi.org/10.1111/j.1468-3083.2011.04410.x .
doi: 10.1111/j.1468-3083.2011.04410.x
pubmed: 22356630
Villasenor-Park J, Wheeler D, Grandinetti L. Psoriasis: evolving treatment for a complex disease. Cleve Clin J Med. 2012;79(6):413–23. https://doi.org/10.3949/ccjm.79a.11133 .
doi: 10.3949/ccjm.79a.11133
pubmed: 22660873
Mease PJ, Armstrong AW. Managing patients with psoriatic disease: the diagnosis and pharmacologic treatment of psoriatic arthritis in patients with psoriasis. Drugs. 2014;74(4):423–41. https://doi.org/10.1007/s40265-014-0191-y .
doi: 10.1007/s40265-014-0191-y
pubmed: 24566842
pmcid: 24566842
Gisondi P, Girolomoni G. Psoriasis and atherothrombotic diseases: disease-specific and non-disease-specific risk factors. Semin Thromb Hemost. 2009;35(3):313–24. https://doi.org/10.1055/s-0029-1222610 .
doi: 10.1055/s-0029-1222610
pubmed: 19452407
Cohen AD, Gilutz H, Henkin Y, et al. Psoriasis and the metabolic syndrome. Acta Derm Venereol. 2007;87(6):506–9. https://doi.org/10.2340/00015555-0297 .
doi: 10.2340/00015555-0297
pubmed: 17989888
Gelfand JM, Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006;296(14):1735–41. https://doi.org/10.1001/jama.296.14.1735 .
doi: 10.1001/jama.296.14.1735
pubmed: 17032986
Gelfand JM, Dommasch ED, Shin DB, et al. The risk of stroke in patients with psoriasis. J Invest Dermatol. 2009;129(10):2411–8. https://doi.org/10.1038/jid.2009.112 .
doi: 10.1038/jid.2009.112
pubmed: 19458634
pmcid: 2864921
Krueger G, Koo J, Lebwohl M, Menter A, Stern RS, Rolstad T. The impact of psoriasis on quality of life: results of a 1998 National Psoriasis Foundation patient-membership survey. Arch Dermatol. 2001;137(3):280–4.
pubmed: 11255325
Langley RG, Krueger GG, Griffiths CE. Psoriasis: epidemiology, clinical features, and quality of life. Ann Rheum Dis. 2005;64(Suppl 2):ii18–23. https://doi.org/10.1136/ard.2004.033217 (discussion ii4-5).
doi: 10.1136/ard.2004.033217
pubmed: 15708928
pmcid: 1766861
Russo PA, Ilchef R, Cooper AJ. Psychiatric morbidity in psoriasis: a review. Australas J Dermatol. 2004;45(3):155–9. https://doi.org/10.1111/j.1440-0960.2004.00078.x (quiz 60-1).
doi: 10.1111/j.1440-0960.2004.00078.x
pubmed: 15250891
Nast A, Gisondi P, Ormerod AD, et al. European S3-guidelines on the systemic treatment of psoriasis vulgaris–update 2015–Short version–EDF in cooperation with EADV and IPC. J Eur Acad Dermatol Venereol. 2015;29(12):2277–94. https://doi.org/10.1111/jdv.13354 .
doi: 10.1111/jdv.13354
pubmed: 26481193
Blauvelt A, Papp KA, Griffiths CE, et al. Efficacy and safety of guselkumab, an anti-interleukin-23 monoclonal antibody, compared with adalimumab for the continuous treatment of patients with moderate to severe psoriasis: results from the phase III, double-blinded, placebo- and active comparator-controlled VOYAGE 1 trial. J Am Acad Dermatol. 2017;76(3):405–17. https://doi.org/10.1016/j.jaad.2016.11.041 .
doi: 10.1016/j.jaad.2016.11.041
pubmed: 28057360
Blauvelt A, Reich K, Tsai TF, et al. Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate-to-severe plaque psoriasis up to 1 year: results from the CLEAR study. J Am Acad Dermatol. 2017;76(1):60–9e9. https://doi.org/10.1016/j.jaad.2016.08.008 .
Langley RG, Elewski BE, Lebwohl M, et al. Secukinumab in plaque psoriasis–results of two phase 3 trials. N Engl J Med. 2014;371(4):326–38. https://doi.org/10.1056/NEJMoa1314258 .
doi: 10.1056/NEJMoa1314258
pubmed: 25007392
Lebwohl M, Strober B, Menter A, et al. Phase 3 studies comparing brodalumab with ustekinumab in psoriasis. N Engl J Med. 2015;373(14):1318–28. https://doi.org/10.1056/NEJMoa1503824 .
doi: 10.1056/NEJMoa1503824
pubmed: 26422722
Leonardi C, Matheson R, Zachariae C, et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med. 2012;366(13):1190–9. https://doi.org/10.1056/NEJMoa1109997 .
doi: 10.1056/NEJMoa1109997
pubmed: 22455413
Leonardi CL, Kimball AB, Papp KA, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). Lancet. 2008;371(9625):1665–74. https://doi.org/10.1016/S0140-6736(08)60725-4 .
doi: 10.1016/S0140-6736(08)60725-4
pubmed: 18486739
Papp KA, Langley RG, Lebwohl M, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet. 2008;371(9625):1675–84. https://doi.org/10.1016/S0140-6736(08)60726-6 .
doi: 10.1016/S0140-6736(08)60726-6
pubmed: 18486740
Papp KA, Leonardi C, Menter A, et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med. 2012;366(13):1181–9. https://doi.org/10.1056/NEJMoa1109017 .
doi: 10.1056/NEJMoa1109017
pubmed: 22455412
Thaci D, Blauvelt A, Reich K, et al. Secukinumab is superior to ustekinumab in clearing skin of subjects with moderate to severe plaque psoriasis: CLEAR, a randomized controlled trial. J Am Acad Dermatol. 2015;73(3):400–9. https://doi.org/10.1016/j.jaad.2015.05.013 .
doi: 10.1016/j.jaad.2015.05.013
pubmed: 26092291
Thaci D, Humeniuk J, Frambach Y, et al. Secukinumab in psoriasis: randomized, controlled phase 3 trial results assessing the potential to improve treatment response in partial responders (STATURE). Br J Dermatol. 2015;173(3):777–87. https://doi.org/10.1111/bjd.13814 .
doi: 10.1111/bjd.13814
pubmed: 25823958
Carretero G, Puig L, Carrascosa JM, et al. Redefining the therapeutic objective in psoriatic patients candidates for biological therapy. J Dermatolog Treat. 2018;29(4):334–46. https://doi.org/10.1080/09546634.2017.1395794 .
doi: 10.1080/09546634.2017.1395794
pubmed: 29099667
Gisondi P, Altomare G, Ayala F, et al. Italian guidelines on the systemic treatments of moderate-to-severe plaque psoriasis. J Eur Acad Dermatol Venereol. 2017;31(5):774–90. https://doi.org/10.1111/jdv.14114 .
doi: 10.1111/jdv.14114
pubmed: 28244153
Gulliver W, Lynde C, Dutz JP, et al. Think beyond the skin: 2014 Canadian expert opinion paper on treating to target in plaque psoriasis. J Cutan Med Surg. 2015;19(1):22–7. https://doi.org/10.2310/7750.2014.13151 .
doi: 10.2310/7750.2014.13151
pubmed: 25775659
Mahil SK, Wilson N, Dand N, et al. Psoriasis treat to target: defining outcomes in psoriasis using data from a real-world, population-based cohort study (the British Association of Dermatologists Biologics and Immunomodulators Register, BADBIR). Br J Dermatol. 2019. https://doi.org/10.1111/bjd.18333 .
doi: 10.1111/bjd.18333
pubmed: 31286471
pmcid: 7317460
Puig L. PASI90 response: the new standard in therapeutic efficacy for psoriasis. J Eur Acad Dermatol Venereol. 2015;29(4):645–8. https://doi.org/10.1111/jdv.12817 .
doi: 10.1111/jdv.12817
pubmed: 25370811
Armstrong AW, Siegel MP, Bagel J, et al. From the Medical Board of the National Psoriasis Foundation: treatment targets for plaque psoriasis. J Am Acad Dermatol. 2017;76(2):290–8. https://doi.org/10.1016/j.jaad.2016.10.017 .
doi: 10.1016/j.jaad.2016.10.017
pubmed: 27908543
Baker C, Mack A, Cooper A, et al. Treatment goals for moderate to severe psoriasis: an Australian consensus. Australas J Dermatol. 2013;54(2):148–54. https://doi.org/10.1111/ajd.12014 .
doi: 10.1111/ajd.12014
pubmed: 23330815
Gladman DD, Poulin Y, Adams K, et al. Treating psoriasis and psoriatic arthritis: position paper on applying the treat-to-target concept to Canadian daily practice. J Rheumatol. 2017;44(4):519–34. https://doi.org/10.3899/jrheum.161473 .
doi: 10.3899/jrheum.161473
pubmed: 28604347
Mrowietz U, Kragballe K, Reich K, et al. Definition of treatment goals for moderate to severe psoriasis: a European consensus. Arch Dermatol Res. 2011;303(1):1–10. https://doi.org/10.1007/s00403-010-1080-1 .
doi: 10.1007/s00403-010-1080-1
pubmed: 20857129
Amatore F, Villani AP, Tauber M, Viguier M, Guillot B, Psoriasis Research Group of the French Society of Dermatology. French guidelines on the use of systemic treatments for moderate-to-severe psoriasis in adults. J Eur Acad Dermatol Venereol. 2019;33(3):464–83. https://doi.org/10.1111/jdv.15340 .
Armstrong A, Jarvis S, Boehncke WH, et al. Patient perceptions of clear/almost clear skin in moderate-to-severe plaque psoriasis: results of the clear about psoriasis worldwide survey. J Eur Acad Dermatol Venereol. 2018;32(12):2200–7. https://doi.org/10.1111/jdv.15065 .
doi: 10.1111/jdv.15065
pubmed: 29730888
Armstrong AW, Koning JW, Rowse S, Tan H, Mamolo C, Kaur M. Under-treatment of patients with moderate to severe psoriasis in the United States: analysis of medication usage with health plan data. Dermatol Ther (Heidelb). 2017;7(1):97–109. https://doi.org/10.1007/s13555-016-0153-2 .
doi: 10.1007/s13555-016-0153-2
Lebwohl MG, Kavanaugh A, Armstrong AW, Van Voorhees AS. US perspectives in the management of psoriasis and psoriatic arthritis: patient and physician results from the population-based multinational assessment of psoriasis and psoriatic arthritis (MAPP) survey. Am J Clin Dermatol. 2016;17(1):87–97. https://doi.org/10.1007/s40257-015-0169-x .
doi: 10.1007/s40257-015-0169-x
pubmed: 26718712
Lynde CW, Beecker J, Dutz J, et al. Treating to target(s) with interleukin-17 inhibitors. J Cutan Med Surg. 2019;23(2_suppl):3S-34S. https://doi.org/10.1177/1203475418824565 .
Hasson F, Keeney S, McKenna H. Research guidelines for the Delphi survey technique. J Adv Nurs. 2000;32(4):1008–15.
pubmed: 11095242
Jones J, Hunter D. Consensus methods for medical and health services research. BMJ. 1995;311(7001):376–80. https://doi.org/10.1136/bmj.311.7001.376 .
doi: 10.1136/bmj.311.7001.376
pubmed: 7640549
pmcid: 7640549
Lakuta P, Marcinkiewicz K, Bergler-Czop B, Brzezinska-Wcislo L, Slomian A. Associations between site of skin lesions and depression, social anxiety, body-related emotions and feelings of stigmatization in psoriasis patients. Postepy Dermatol Alergol. 2018;35(1):60–6. https://doi.org/10.5114/pdia.2016.62287 .
doi: 10.5114/pdia.2016.62287
pubmed: 29599673
pmcid: 5872236
Bardazzi F, Starace M, Bruni F, Magnano M, Piraccini BM, Alessandrini A. Nail psoriasis: an updated review and expert opinion on available treatments, including biologics. Acta Derm Venereol. 2019;99(6):516–23. https://doi.org/10.2340/00015555-3098 .
doi: 10.2340/00015555-3098
pubmed: 30521057
Dopytalska K, Sobolewski P, Blaszczak A, Szymanska E, Walecka I. Psoriasis in special localizations. Reumatologia. 2018;56(6):392–8. https://doi.org/10.5114/reum.2018.80718 .
doi: 10.5114/reum.2018.80718
pubmed: 30647487
pmcid: 6330687
Strober B, Papp KA, Lebwohl M, et al. Clinical meaningfulness of complete skin clearance in psoriasis. J Am Acad Dermatol. 2016;75(1):77–82e7. https://doi.org/10.1016/j.jaad.2016.03.026 .
Bai F, Li GG, Liu Q, Niu X, Li R, Ma H. Short-term efficacy and safety of IL-17, IL-12/23, and IL-23 inhibitors brodalumab, secukinumab, ixekizumab, ustekinumab, guselkumab, tildrakizumab, and risankizumab for the treatment of moderate to severe plaque psoriasis: a systematic review and network meta-analysis of randomized controlled trials. J Immunol Res. 2019;2019:2546161. https://doi.org/10.1155/2019/2546161 .
doi: 10.1155/2019/2546161
pubmed: 31583255
pmcid: 6754904
Gordon KB, Reich K, Crowley JJ, et al. Disease activity and treatment efficacy using patient-level Psoriasis Area and Severity Index scores from tildrakizumab phase 3 clinical trials. J Dermatolog Treat. 2020:1–10. https://doi.org/10.1080/09546634.2020.1747590 .
Hongbo Y, Thomas CL, Harrison MA, Salek MS, Finlay AY. Translating the science of quality of life into practice: what do dermatology life quality index scores mean? J Invest Dermatol. 2005;125(4):659–64. https://doi.org/10.1111/j.0022-202X.2005.23621.x .
doi: 10.1111/j.0022-202X.2005.23621.x
pubmed: 16185263
Korman NJ, Zhao Y, Pike J, Roberts J. Relationship between psoriasis severity, clinical symptoms, quality of life and work productivity among patients in the USA. Clin Exp Dermatol. 2016;41(5):514–21. https://doi.org/10.1111/ced.12841 .
doi: 10.1111/ced.12841
pubmed: 27061102
Leman J, Walton S, Layton AM, et al. The real world impact of adalimumab on quality of life and the physical and psychological effects of moderate-to-severe psoriasis: a UK prospective, multicenter, observational study. J Dermatolog Treat. 2019:1–9. https://doi.org/10.1080/09546634.2019.1592096 .
Puig L, Augustin M, Blauvelt A, et al. Effect of secukinumab on quality of life and psoriasis-related symptoms: a comparative analysis versus ustekinumab from the CLEAR 52-week study. J Am Acad Dermatol. 2018;78(4):741–8. https://doi.org/10.1016/j.jaad.2017.10.025 .
doi: 10.1016/j.jaad.2017.10.025
pubmed: 29066271
Hjuler KF, Gormsen LC, Vendelbo MH, Egeberg A, Nielsen J, Iversen L. Increased global arterial and subcutaneous adipose tissue inflammation in patients with moderate-to-severe psoriasis. Br J Dermatol. 2017;176(3):732–40. https://doi.org/10.1111/bjd.15149 .
doi: 10.1111/bjd.15149
pubmed: 27787888
Kerdel F, Don F. The importance of early treatment in psoriasis and management of disease progression. J Drugs Dermatol. 2018;17(7):737–42.
pubmed: 30005095
Pietrzak D, Pietrzak A, Grywalska E, et al. Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis. PLoS One. 2018;13(8):e0201589. https://doi.org/10.1371/journal.pone.0201589 .
doi: 10.1371/journal.pone.0201589
pubmed: 30092066
pmcid: 6084948
Mease PJ, Gladman DD, Papp KA, et al. Prevalence of rheumatologist-diagnosed psoriatic arthritis in patients with psoriasis in European/North American dermatology clinics. J Am Acad Dermatol. 2013;69(5):729–35. https://doi.org/10.1016/j.jaad.2013.07.023 .
doi: 10.1016/j.jaad.2013.07.023
pubmed: 23981683
Elnabawi YA, Dey AK, Goyal A, et al. Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study. Cardiovasc Res. 2019;115(4):721–8. https://doi.org/10.1093/cvr/cvz009 .
doi: 10.1093/cvr/cvz009
pubmed: 30721933
pmcid: 6432047
von Stebut E, Reich K, Thaci D, et al. Impact of secukinumab on endothelial dysfunction and other cardiovascular disease parameters in psoriasis patients over 52 weeks. J Invest Dermatol. 2019;139(5):1054–62. https://doi.org/10.1016/j.jid.2018.10.042 .
doi: 10.1016/j.jid.2018.10.042
Deodhar A, Mease PJ, McInnes IB, et al. Long-term safety of secukinumab in patients with moderate-to-severe plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis: integrated pooled clinical trial and post-marketing surveillance data. Arthritis Res Ther. 2019;21(1):111. https://doi.org/10.1186/s13075-019-1882-2 .
doi: 10.1186/s13075-019-1882-2
pubmed: 31046809
pmcid: 6498580
Gisondi P, Tessari G, di Mercurio M, Del Giglio M, Girolomoni G. Retention rate of systemic drugs in patients with chronic plaque psoriasis. Clin Dermatol. 2013;1(1):8–14.
Howell ST, Cardwell LA, Feldman SR. Treating moderate-to-severe plaque psoriasis with guselkumab: a review of phase II and phase III trials. Ann Pharmacother. 2018;52(4):380–7. https://doi.org/10.1177/1060028017743268 .
doi: 10.1177/1060028017743268
pubmed: 29134822
Kimball AB, Rothman KJ, Kricorian G, et al. OBSERVE-5: observational postmarketing safety surveillance registry of etanercept for the treatment of psoriasis final 5-year results. J Am Acad Dermatol. 2015;72(1):115–22. https://doi.org/10.1016/j.jaad.2014.08.050 .
doi: 10.1016/j.jaad.2014.08.050
pubmed: 25264239
Langley RG, Kimball AB, Nak H, et al. Long-term safety profile of ixekizumab in patients with moderate-to-severe plaque psoriasis: an integrated analysis from 11 clinical trials. J Eur Acad Dermatol Venereol. 2019;33(2):333–9. https://doi.org/10.1111/jdv.15242 .
doi: 10.1111/jdv.15242
pubmed: 30198588
Strober B, Crowley J, Langley RG, et al. Systematic review of the real-world evidence of adalimumab safety in psoriasis registries. J Eur Acad Dermatol Venereol. 2018;32(12):2126–33. https://doi.org/10.1111/jdv.15203 .
doi: 10.1111/jdv.15203
pubmed: 30067882
Gottlieb AB, Kalb RE, Langley RG, et al. Safety observations in 12095 patients with psoriasis enrolled in an international registry (PSOLAR): experience with infliximab and other systemic and biologic therapies. J Drugs Dermatol. 2014;13(12):1441–8.
pubmed: 25607786
Papp K, Gottlieb AB, Naldi L, et al. Safety surveillance for ustekinumab and other psoriasis treatments from the Psoriasis Longitudinal Assessment and Registry (PSOLAR). J Drugs Dermatol. 2015;14(7):706–14.
pubmed: 26151787
Warren RB, Smith CH, Yiu ZZN, et al. Differential drug survival of biologic therapies for the treatment of psoriasis: a prospective observational cohort study from the British Association of Dermatologists Biologic Interventions Register (BADBIR). J Invest Dermatol. 2015;135(11):2632–40. https://doi.org/10.1038/jid.2015.208 .
doi: 10.1038/jid.2015.208
pubmed: 26053050
Menter A, Papp KA, Gooderham M, et al. Drug survival of biologic therapy in a large, disease-based registry of patients with psoriasis: results from the Psoriasis Longitudinal Assessment and Registry (PSOLAR). J Eur Acad Dermatol Venereol. 2016;30(7):1148–58. https://doi.org/10.1111/jdv.13611 .
doi: 10.1111/jdv.13611
pubmed: 27027388
pmcid: 5071685