Risk of seropositivity to Coxiella burnetii in humans living in areas with endemically infected cattle: No way for specific prevention.
Q fever
cattle
human
prevention
risk factors
zoonosis
Journal
Zoonoses and public health
ISSN: 1863-2378
Titre abrégé: Zoonoses Public Health
Pays: Germany
ID NLM: 101300786
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
12
06
2020
revised:
24
11
2020
accepted:
26
12
2020
pubmed:
12
1
2021
medline:
14
4
2021
entrez:
11
1
2021
Statut:
ppublish
Résumé
Q fever, a zoonotic disease caused by Coxiella burnetii, is endemic among cattle in Western France. However, studies assessing the risk of human infection in such areas are lacking to date, while they may provide information about key specific preventive actions which could be advised to the human populations living with or close to cattle. Therefore, we conducted a cross-sectional study in two departments of Western France during the 2017/18 winter in order to explore possible risk factors for seropositivity among two distinct populations, i) an occupational risk group, that is, the cattle farmers, and ii) the general adult population (approached by blood donors). Sera were collected in 176 cattle farmers and 347 blood donors respectively, and tested for phase I and II antibodies using an indirect immunofluorescence antibody assay. Each participant was asked to fill in a questionnaire containing socio-demographic characteristics, occupational and non-occupational risk exposure. Identified risk factors were: in the general population, working in contact with ruminants, comparatively to any other activity (OR = 4.41; 95% CI: [1.59-6.55]); among farmers, managing an itself infected cattle herd (OR = 3.20; 95% CI: [1.59-6.55]). No other controllable risk factor (lifestyle, outdoor activities, proximity to pets and livestock animals, occupational practices) was here evidenced. In areas with endemically infected cattle, human exposure to Coxiella burnetii is to some extent unavoidable. This strengthens the need for physicians' awareness of the symptoms of Q fever and the appropriateness of general biosecurity measures, especially among at-risk groups living there.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
144-152Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
Arricau-Bouvery, N., & Rodolakis, A. (2005). Is Q fever an emerging or re-emerging zoonosis? Veterinary Research, 36, 327-349. https://doi.org/10.1051/vetres:2005010
Dijkstra, F., van der Hoek, W., Wijers, N., Schimmer, B., Rietveld, A., Wijkmans, C. J., Vellema, P., & Schneeberger, P. M. (2012). The 2007-2010 Q fever epidemic in the Netherlands: Characteristics of notified acute Q fever patients and the association with dairy goat farming. FEMS Immunology and Medical Microbiology, 64, 3-12. https://doi.org/10.1111/j.1574-695X.2011.00876.x
Georgiev, M., Afonso, A., Neubauer, H., Needham, H., Thiéry, R., Rodolakis, A., Roest, H. J., Stärk, K. D., Stegeman, J. A., Vellema, P., van der Hoek, W., & More, S. J. (2013). Q fever in humans and farm animals in four European countries, 1982 to2010. Eurosurveillance, 18, 20407.
Gidding, H. F., Wallace, C., Lawrence, G. L., & McIntyre, P. B. (2009). Australia’s national Q fever vaccination program. Vaccine, 27, 2037-2041.
Greenland, S., Daniel, R., & Pierce, N. (2016). Outcome modelling strategies in epidemiology: Traditional methods and basic alternatives. International Journal of Epidemiology, 45, 565-575. https://doi.org/10.1093/ije/dyw040
HCSP - Haut Conseil de la Santé Publique 2013. Rapport: Fièvre Q, recommandations de prise en charge. Retrieved from https://www.hcsp.fr/explore.cgi/avisrapportsdomaine?clefr=401
Maurin, M., & Raoult, D. (1999). Q Fever. Clinical Microbiology Review, 12, 518-553. https://doi.org/10.1128/CMR.12.4.518
Nusinovici, S., Hoch, T., Widgren, S., Joly, A., Lindberg, A., & Beaudeau, F. (2014). Relative contributions of neighborhood and animal movements to Coxiella burnetii infection in dairy cattle herds. Geospatial Health, 8, 471-477.
Schimmer, B., Schotten, N., van Engelen, E., Hautvast, J. L. A., Schneeberger, P. M., & van Duijnhoven, Y. T. H. P. (2014). Coxiella burnetii seroprevalence and risk for humans on dairy cattle farms, the Netherlands, 2010-2011. Emerging Infectious Diseases, 20, 417-425.
van der Hoek, W., Dijkstra, F., Vellema, P., Wijkmans, C., ter Schegget, R., Hackert, V., & van Duynhoven, Y. (2010). Q fever in the Netherlands: An update on the epidemiology and control measures. Eurosurveillance, 15, 4-7.
Wielders, C. C., Kampschreur, L. M., Schneeberger, P. M., Jager, M. M., Hoepelman, A. I., Leenders, A. C., Hermans, M. H., & Wever, P. C. (2012). Early diagnosis and treatment of patients with symptomatic acute Q fever do not prohibit IgG antibody responses to Coxiella burnetii. Clinical and Vaccine Immunology, 19, 1661-1666. https://doi.org/10.1128/CVI.00322-12