Current Concepts and Advances in Graft-Versus-Host Disease Immunology.
graft-versus-host disease
pathophysiology
prevention
regulation
therapy
tolerance
Journal
Annual review of immunology
ISSN: 1545-3278
Titre abrégé: Annu Rev Immunol
Pays: United States
ID NLM: 8309206
Informations de publication
Date de publication:
26 04 2021
26 04 2021
Historique:
pubmed:
12
1
2021
medline:
26
10
2021
entrez:
11
1
2021
Statut:
ppublish
Résumé
Worldwide, each year over 30,000 patients undergo an allogeneic hema-topoietic stem cell transplantation with the intent to cure high-risk hematologic malignancy, immunodeficiency, metabolic disease, or a life-threatening bone marrow failure syndrome. Despite substantial advances in donor selection and conditioning regimens and greater availability of allograft sources, transplant recipients still endure the morbidity and mortality of graft-versus-host disease (GVHD). Herein, we identify key aspects of acute and chronic GVHD pathophysiology, including host/donor cell effectors, gut dysbiosis, immune system and cytokine imbalance, and the interface between inflammation and tissue fibrosis. In particular, we also summarize the translational application of this heightened understanding of immune dysregulation in the design of novel therapies to prevent and treat GVHD.
Identifiants
pubmed: 33428454
doi: 10.1146/annurev-immunol-102119-073227
pmc: PMC8085043
mid: NIHMS1668678
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-49Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL133823
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL095791
Pays : United States
Organisme : FDA HHS
ID : R01 FD004099
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA065493
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118979
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI051731
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147324
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI034495
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155114
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL056067
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA244291
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI056299
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148164
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA142106
Pays : United States
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