Membrane cholesterol regulates endocytosis and trafficking of the serotonin
Cholesterol
Endocytosis
GPCR
Intracellular trafficking
MβCD
Serotonin(1A) receptor
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
10
10
2020
revised:
24
12
2020
accepted:
06
01
2021
pubmed:
12
1
2021
medline:
2
7
2021
entrez:
11
1
2021
Statut:
ppublish
Résumé
Endocytosis and intracellular trafficking constitute important regulatory features associated with G protein-coupled receptor (GPCR) function. GPCR endocytosis involves several remodeling events at the plasma membrane orchestrated by a concerted interplay of a large number of proteins and membrane lipids. Although considerable literature exists on the protein framework underlying GPCR endocytosis, the role of membrane lipids in this process remains largely unexplored. In order to explore the role of membrane cholesterol (an essential and important lipid in higher eukaryotes) in GPCR endocytosis, we monitored the effect of acute cholesterol depletion using methyl-β-cyclodextrin (MβCD) on endocytosis and intracellular trafficking of the serotonin
Identifiants
pubmed: 33429076
pii: S1388-1981(21)00008-1
doi: 10.1016/j.bbalip.2021.158882
pii:
doi:
Substances chimiques
Receptor, Serotonin, 5-HT1A
112692-38-3
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
158882Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.