The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification.
KCGS
chemogenomic set
drug discovery
druggable genome
kinase inhibitor
phenotypic screening
protein kinase
small molecules
understudied kinase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Jan 2021
08 Jan 2021
Historique:
received:
08
12
2020
accepted:
29
12
2020
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
31
3
2021
Statut:
epublish
Résumé
We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.
Identifiants
pubmed: 33429995
pii: ijms22020566
doi: 10.3390/ijms22020566
pmc: PMC7826789
pii:
doi:
Substances chimiques
Protein Kinase Inhibitors
0
Small Molecule Libraries
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : 1R44TR001916-02
Pays : United States
Organisme : Innovative Medicines Initiative
ID : 875510
Organisme : NIH HHS
ID : 1U24DK116204-01
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218442
Pays : United States
Organisme : NIH HHS
ID : 1R01CA218442-01
Pays : United States
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