Assessment of Physico-Chemical and Toxicological Properties of Commercial 2D Boron Nitride Nanopowder and Nanoplatelets.
2D boron nitride
cell viability
eukaryotic model
nanotoxicity
oxidative stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Jan 2021
08 Jan 2021
Historique:
received:
02
12
2020
revised:
03
01
2021
accepted:
05
01
2021
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
31
3
2021
Statut:
epublish
Résumé
Boron nitride (BN) nanomaterials have been increasingly explored for potential applications in chemistry and biology fields (e.g., biomedical, pharmaceutical, and energy industries) due to their unique physico-chemical properties. However, their safe utilization requires a profound knowledge on their potential toxicological and environmental impact. To date, BN nanoparticles have been considered to have a high biocompatibility degree, but in some cases, contradictory results on their potential toxicity have been reported. Therefore, in the present study, we assessed two commercial 2D BN samples, namely BN-nanopowder (BN-PW) and BN-nanoplatelet (BN-PL), with the objective to identify whether distinct physico-chemical features may have an influence on the biological responses of exposed cellular models. Morphological, structural, and composition analyses showed that the most remarkable difference between both commercial samples was the diameter of their disk-like shape, which was of 200-300 nm for BN-PL and 100-150 nm for BN-PW. Their potential toxicity was investigated using adenocarcinomic human alveolar basal epithelial cells (A549 cells) and the unicellular fungus
Identifiants
pubmed: 33430016
pii: ijms22020567
doi: 10.3390/ijms22020567
pmc: PMC7827597
pii:
doi:
Substances chimiques
Boron Compounds
0
Reactive Oxygen Species
0
boron nitride
2U4T60A6YD
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : H2020-MSCA-ITN
ID : 721642
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