Inflammation in the Human Periodontium Induces Downregulation of the α
Animals
Antigens, CD
/ metabolism
Antigens, Differentiation, Myelomonocytic
/ metabolism
Cyclic GMP
/ genetics
Gene Expression Regulation
/ genetics
Heme
/ genetics
Humans
Inflammation
/ genetics
Iron
/ metabolism
Nitric Oxide
/ genetics
Osteoclasts
/ metabolism
Oxidation-Reduction
/ drug effects
Periodontal Ligament
/ metabolism
Periodontium
/ metabolism
Soluble Guanylyl Cyclase
/ genetics
alveolar bone
cGMP
cementoclasts
cementum
nitric oxide
osteoclasts
periodontitis
soluble guanylyl cyclase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Jan 2021
07 Jan 2021
Historique:
received:
12
11
2020
revised:
30
12
2020
accepted:
05
01
2021
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
31
3
2021
Statut:
epublish
Résumé
Nitric oxide (NO) binds to soluble guanylyl cyclase (sGC), activates it in a reduced oxidized heme iron state, and generates cyclic Guanosine Monophosphate (cGMP), which results in vasodilatation and inhibition of osteoclast activity. In inflammation, sGC is oxidized and becomes insensitive to NO. NO- and heme-independent activation of sGC requires protein expression of the α
Identifiants
pubmed: 33430449
pii: ijms22020539
doi: 10.3390/ijms22020539
pmc: PMC7827426
pii:
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
CD68 antigen, human
0
Nitric Oxide
31C4KY9ESH
Heme
42VZT0U6YR
Iron
E1UOL152H7
Soluble Guanylyl Cyclase
EC 4.6.1.2
Cyclic GMP
H2D2X058MU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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