Chlorpyrifos with Age-Dependent Effects in Cardiac Tissue of Male Rats.
Chlorpyrifos
aging
cardiovascular diseases
heart
oxidative stress
rat.
Journal
Current molecular pharmacology
ISSN: 1874-4702
Titre abrégé: Curr Mol Pharmacol
Pays: United Arab Emirates
ID NLM: 101467997
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
08
2020
revised:
21
11
2020
accepted:
23
11
2020
pubmed:
13
1
2021
medline:
1
4
2022
entrez:
12
1
2021
Statut:
ppublish
Résumé
Age-dependent toxic effects of organophosphorus pesticides (OPs) have not been fully understood. The current study aimed to investigate the cardiotoxic damage of chlorpyrifos (CPF) by evaluating oxidative modifications in young (2-month old), middle-aged (10- month old), and aged (20-month old) rats. Five mg/kg of CPF was administered orally for 45 days to young, middle-aged, and aged male Wistar rats. In the end, animals were anesthetized and the heart of each rat was dissected for biochemical assay. Malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were assessed in the cardiac tissue of rats. The results indicated an increase in the levels of MDA and NO, and also a decline in the levels of GSH and TAC as well as a decrease in the SOD activity in the heart of aged rats compared with young rats. CPF administration deteriorated these changes in the heart of exposed rats compared with the age-matched controls. Additionally, these oxidative modifications were more severe in aged rats versus other age. In conclusion, advancing age may increase oxidative changes in the heart of animals exposed to CPF. It is suggested that aging can affect cardiac toxicity induced by OPs.
Sections du résumé
BACKGROUND
Age-dependent toxic effects of organophosphorus pesticides (OPs) have not been fully understood. The current study aimed to investigate the cardiotoxic damage of chlorpyrifos (CPF) by evaluating oxidative modifications in young (2-month old), middle-aged (10- month old), and aged (20-month old) rats.
OBJECTIVE
Five mg/kg of CPF was administered orally for 45 days to young, middle-aged, and aged male Wistar rats. In the end, animals were anesthetized and the heart of each rat was dissected for biochemical assay.
METHODS
Malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were assessed in the cardiac tissue of rats.
RESULTS
The results indicated an increase in the levels of MDA and NO, and also a decline in the levels of GSH and TAC as well as a decrease in the SOD activity in the heart of aged rats compared with young rats. CPF administration deteriorated these changes in the heart of exposed rats compared with the age-matched controls. Additionally, these oxidative modifications were more severe in aged rats versus other age.
CONCLUSION
In conclusion, advancing age may increase oxidative changes in the heart of animals exposed to CPF. It is suggested that aging can affect cardiac toxicity induced by OPs.
Identifiants
pubmed: 33430739
pii: CMP-EPUB-113155
doi: 10.2174/1874467214666210111105321
doi:
Substances chimiques
Organophosphorus Compounds
0
Pesticides
0
Chlorpyrifos
JCS58I644W
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
894-899Informations de copyright
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