Adult Attachment System Links With Brain Mu Opioid Receptor Availability In Vivo.

Adult Brain / diagnostic imaging Brain Mapping Humans Individuality Positron-Emission Tomography Receptors, Opioid, mu / metabolism
Attachment Neurotransmission Opioid Positron emission tomography Serotonin

Journal

Biological psychiatry. Cognitive neuroscience and neuroimaging
ISSN: 2451-9030
Titre abrégé: Biol Psychiatry Cogn Neurosci Neuroimaging
Pays: United States
ID NLM: 101671285

Informations de publication

Date de publication:
03 2021
Historique:
received: 07 07 2020
revised: 05 10 2020
accepted: 22 10 2020
pubmed: 13 1 2021
medline: 4 6 2021
entrez: 12 1 2021
Statut: ppublish

Résumé

Secure attachment is important in maintaining an individual's health and well-being. Attachment disturbances increase the risk for developing psychiatric disorders such as affective disorders. Yet, the neurobiological correlates of human attachment are poorly understood at the neurotransmitter level. We investigated whether adult attachment style is linked to functioning of the opioid and serotonergic systems in the human brain. We used positron emission tomography with radioligands [ Secure attachment was associated with higher mu opioid receptor availability in the hippocampus, amygdala, thalamus, and prefrontal cortex when compared with insecure (i.e., avoidant or ambivalent groups combined) attachment. In contrast, attachment style was not associated with serotonin transporter availability. Our results provide preliminary in vivo evidence that the opioid system may be involved in the neurocircuits associated with individual differences in adult attachment behavior. The results suggest that variation in mu opioid receptor availability may be linked with the individuals' social relationships and psychosocial well-being and thus contributes to risk for psychiatric morbidity.

Sections du résumé

BACKGROUND
Secure attachment is important in maintaining an individual's health and well-being. Attachment disturbances increase the risk for developing psychiatric disorders such as affective disorders. Yet, the neurobiological correlates of human attachment are poorly understood at the neurotransmitter level. We investigated whether adult attachment style is linked to functioning of the opioid and serotonergic systems in the human brain.
METHODS
We used positron emission tomography with radioligands [
RESULTS
Secure attachment was associated with higher mu opioid receptor availability in the hippocampus, amygdala, thalamus, and prefrontal cortex when compared with insecure (i.e., avoidant or ambivalent groups combined) attachment. In contrast, attachment style was not associated with serotonin transporter availability.
CONCLUSIONS
Our results provide preliminary in vivo evidence that the opioid system may be involved in the neurocircuits associated with individual differences in adult attachment behavior. The results suggest that variation in mu opioid receptor availability may be linked with the individuals' social relationships and psychosocial well-being and thus contributes to risk for psychiatric morbidity.

Identifiants

DOI: 10.1016/j.bpsc.2020.10.013 PMID: 33431346
pubmed: 33431346
pii: S2451-9022(20)30317-7
doi: 10.1016/j.bpsc.2020.10.013
pii:
doi:

Substances chimiques

Receptors, Opioid, mu 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

360-369

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Auteurs

Otto Turtonen (O)

Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.

Aino Saarinen (A)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Research Unit of Psychology, University of Oulu, Oulu, Finland.

Lauri Nummenmaa (L)

Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland; Department of Psychology, University of Turku, Turku, Finland.

Lauri Tuominen (L)

Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland; Department of Psychiatry, Turku University Hospital and University of Turku, Turku, Finland; Institute of Mental Health Research, Royal Ottawa Mental Health Centre, Ottawa, Ontario, Canada.

Maria Tikka (M)

Department of Psychiatry, Turku University Hospital and University of Turku, Turku, Finland.

Reetta-Liina Armio (RL)

Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland; Department of Psychiatry, Turku University Hospital and University of Turku, Turku, Finland.

Airi Hautamäki (A)

Swedish School of Social Science, University of Helsinki, Helsinki, Finland.

Heikki Laurikainen (H)

Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland; Department of Psychiatry, Turku University Hospital and University of Turku, Turku, Finland.

Olli Raitakari (O)

Research Centre of Applied and Preventive Cardiovascular Medicine, Faculty of Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.

Liisa Keltikangas-Järvinen (L)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Jarmo Hietala (J)

Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland; Department of Psychiatry, Turku University Hospital and University of Turku, Turku, Finland. Electronic address: jahi@utu.fi.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adult Attachment System Links With Brain Mu...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Adult Attachment System Links With Brain Mu...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Adult Attachment System Links With Brain Mu...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Adult Attachment System Links With Brain Mu...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Personnalité › Individualité › Adult Attachment System Links With Brain Mu...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Adult Attachment System Links With Brain Mu...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur mu › Adult Attachment System Links With Brain Mu...