Ultraviolet radiation drives mutations in a subset of mucosal melanomas.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 01 2021
11 01 2021
Historique:
received:
10
07
2020
accepted:
25
11
2020
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
22
1
2021
Statut:
epublish
Résumé
Although identified as the key environmental driver of common cutaneous melanoma, the role of ultraviolet radiation (UVR)-induced DNA damage in mucosal melanoma is poorly defined. We analyze 10 mucosal melanomas of conjunctival origin by whole genome sequencing and our data shows a predominance of UVR-associated single base substitution signature 7 (SBS7) in the majority of the samples. Our data shows mucosal melanomas with SBS7 dominance have similar genomic patterns to cutaneous melanomas and therefore this subset should not be excluded from treatments currently used for common cutaneous melanoma.
Identifiants
pubmed: 33431815
doi: 10.1038/s41467-020-20432-5
pii: 10.1038/s41467-020-20432-5
pmc: PMC7801393
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
259Subventions
Organisme : Cancer Research UK
ID : A27412
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Cancer Research UK
ID : A22902
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100282/Z/12/Z
Pays : United Kingdom
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