NOD2 deficiency increases retrograde transport of secretory IgA complexes in Crohn's disease.
Animals
Colitis
/ microbiology
Crohn Disease
/ metabolism
Humans
Immunoglobulin A, Secretory
/ metabolism
Lectins, C-Type
/ metabolism
Mice, Knockout
Models, Biological
Mutation
/ genetics
Nod2 Signaling Adaptor Protein
/ deficiency
Peyer's Patches
/ metabolism
Protein Transport
Salmonella
/ physiology
Sialic Acid Binding Immunoglobulin-like Lectins
/ metabolism
Transcytosis
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 01 2021
11 01 2021
Historique:
received:
20
05
2019
accepted:
23
10
2020
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
22
1
2021
Statut:
epublish
Résumé
Intestinal microfold cells are the primary pathway for translocation of secretory IgA (SIgA)-pathogen complexes to gut-associated lymphoid tissue. Uptake of SIgA/commensals complexes is important for priming adaptive immunity in the mucosa. This study aims to explore the effect of SIgA retrograde transport of immune complexes in Crohn's disease (CD). Here we report a significant increase of SIgA transport in CD patients with NOD2-mutation compared to CD patients without NOD2 mutation and/or healthy individuals. NOD2 has an effect in the IgA transport through human and mouse M cells by downregulating Dectin-1 and Siglec-5 expression, two receptors involved in retrograde transport. These findings define a mechanism of NOD2-mediated regulation of mucosal responses to intestinal microbiota, which is involved in CD intestinal inflammation and dysbiosis.
Identifiants
pubmed: 33431850
doi: 10.1038/s41467-020-20348-0
pii: 10.1038/s41467-020-20348-0
pmc: PMC7801705
doi:
Substances chimiques
Immunoglobulin A, Secretory
0
Lectins, C-Type
0
Nod2 Signaling Adaptor Protein
0
Sialic Acid Binding Immunoglobulin-like Lectins
0
Siglecf protein, mouse
0
dectin 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
261Références
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