Defining a therapeutic range for regeneration of ischemic myocardium via shock waves.
Animals
Cells, Cultured
Dose-Response Relationship, Radiation
Extracorporeal Shockwave Therapy
/ methods
Heart
/ physiology
High-Energy Shock Waves
/ therapeutic use
Human Umbilical Vein Endothelial Cells
Humans
Male
Mice
Mice, Inbred C57BL
Myocardial Ischemia
/ pathology
Myocardium
/ pathology
Radiation Dosage
Regeneration
/ physiology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 01 2021
11 01 2021
Historique:
received:
13
12
2019
accepted:
14
12
2020
entrez:
12
1
2021
pubmed:
13
1
2021
medline:
8
9
2021
Statut:
epublish
Résumé
Shockwave therapy (SWT) represents a promising regenerative treatment option for patients with ischemic cardiomyopathy. Although no side-effects have been described upon SWT, potential cellular damage at therapeutic energies has not been addressed so far. In this work, we aimed to define a therapeutic range for shock wave application for myocardial regeneration. We could demonstrate that SWT does not induce cellular damage beneath energy levels of 0.27 mJ/mm
Identifiants
pubmed: 33432034
doi: 10.1038/s41598-020-79776-z
pii: 10.1038/s41598-020-79776-z
pmc: PMC7801389
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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