Cross-sectional and longitudinal associations between psychotic and depressive symptoms in depressed adolescents.
Adolescence
Depression severity
Psychotic symptoms
Unipolar depression
Journal
European child & adolescent psychiatry
ISSN: 1435-165X
Titre abrégé: Eur Child Adolesc Psychiatry
Pays: Germany
ID NLM: 9212296
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
02
07
2020
accepted:
07
12
2020
pubmed:
13
1
2021
medline:
1
6
2022
entrez:
12
1
2021
Statut:
ppublish
Résumé
Adults with major depressive disorder (MDD) with psychotic features (delusions and/or hallucinations) have more severe symptoms and a worse prognosis. Subclinical psychotic symptoms are more common in adolescents than adults. However, the effects of psychotic symptoms on outcome of depressive symptoms have not been well studied in adolescents. Depressed adolescents aged 11-17 with and without psychotic symptoms were compared on depression severity scores at baseline and at 28- or 42-week follow-up in two large UK cohorts. Psychotic symptoms were weakly associated with more severe depression at baseline in both cohorts. At follow-up, baseline psychotic symptoms were only associated with depressive symptoms in one sample; in the other, the effect size was close to zero. This supports the DSM5 system of psychotic symptoms being a separate code to severity rather than the ICD10 system which only allows the diagnosis of psychotic depression with severe depression. There was no clear support for psychotic symptoms being a baseline marker of treatment response.
Identifiants
pubmed: 33432401
doi: 10.1007/s00787-020-01704-3
pii: 10.1007/s00787-020-01704-3
pmc: PMC9142412
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
729-736Subventions
Organisme : Department of Health
ID : 06/05/01
Pays : United Kingdom
Organisme : Health Technology Assessment Programme
ID : 06/05/01
Informations de copyright
© 2021. The Author(s).
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