Association of remote mild traumatic brain injury with cortical amyloid burden in clinically normal older adults.
Aging
Amyloid
Concussion
Dementia
Neurodegenerative
PET
Traumatic brain injury
Journal
Brain imaging and behavior
ISSN: 1931-7565
Titre abrégé: Brain Imaging Behav
Pays: United States
ID NLM: 101300405
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
01
09
2020
accepted:
22
12
2020
revised:
18
12
2020
pubmed:
13
1
2021
medline:
13
10
2021
entrez:
12
1
2021
Statut:
ppublish
Résumé
We investigated whether clinically normal older adults with remote, mild traumatic brain injury (mTBI) show evidence of higher cortical Aβ burden. Our study included 134 clinically normal older adults (age 74.1 ± 6.8 years, 59.7% female, 85.8% white) who underwent Aβ positron emission tomography (Aβ-PET) and who completed the Ohio State University Traumatic Brain Injury Identification questionnaire. We limited participants to those reporting injuries classified as mTBI. A subset (N = 30) underwent a second Aβ-PET scan (mean 2.7 years later). We examined the effect of remote mTBI on Aβ-PET burden, interactions between remote mTBI and age, sex, and APOE status, longitudinal Aβ accumulation, and the interaction between remote mTBI and Aβ burden on memory and executive functioning. Of 134 participants, 48 (36%) reported remote mTBI (0, N = 86; 1, N = 31, 2+, N = 17; mean 37 ± 23 years since last mTBI). Effect size estimates were small to negligible for the association of remote mTBI with Aβ burden (p = .94, η
Identifiants
pubmed: 33432536
doi: 10.1007/s11682-020-00440-1
pii: 10.1007/s11682-020-00440-1
pmc: PMC8272743
mid: NIHMS1663520
doi:
Substances chimiques
Amyloid
0
Amyloid beta-Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2417-2425Subventions
Organisme : NIA NIH HHS
ID : R01AG032289, R01AG048234
Pays : United States
Organisme : NIA NIH HHS
ID : P50AG023501, P30AG062422
Pays : United States
Organisme : NIA NIH HHS
ID : K24 AG045333
Pays : United States
Organisme : Larry L. Hillblom Foundation
ID : 2014-A-004-NET
Organisme : NIA NIH HHS
ID : K23AG058752
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG032289
Pays : United States
Organisme : Larry L. Hillblom Foundation
ID : 2018-A-025-FEL
Organisme : NIA NIH HHS
ID : K23 AG058752
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG045611
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS095755
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG065501
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG032289
Pays : United States
Organisme : Alzheimer's Association
ID : AARF-16-443577
Pays : United States
Organisme : NIA NIH HHS
ID : K23AG061253
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045611
Pays : United States
Organisme : NIA NIH HHS
ID : K99AG065501
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG061253
Pays : United States
Organisme : NINDS NIH HHS
ID : (K23NS095755
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048234
Pays : United States
Organisme : American Academy of Neurology, American Brain Foundation, Alzheimer's Association
ID : Robert W. Katzman Fellowship Training Grant
Organisme : NIA NIH HHS
ID : T32 AG023481
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
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