Epigenetic regulation of
LncRNA
Wnt7b
cell biology
chromatin
epigenetics
human
mouse
muscle stem cells
ncRNA
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 01 2021
12 01 2021
Historique:
received:
30
12
2019
accepted:
11
01
2021
pubmed:
13
1
2021
medline:
4
2
2022
entrez:
12
1
2021
Statut:
epublish
Résumé
Skeletal muscle possesses an outstanding capacity to regenerate upon injury due to the adult muscle stem cell (MuSC) activity. This ability requires the proper balance between MuSC expansion and differentiation, which is critical for muscle homeostasis and contributes, if deregulated, to muscle diseases. Here, we functionally characterize a novel chromatin-associated long noncoding RNA (lncRNA), Lnc-Rewind, which is expressed in murine MuSCs and conserved in human. We find that, in mouse, Lnc-Rewind acts as an epigenetic regulator of MuSC proliferation and expansion by influencing the expression of skeletal muscle genes and several components of the WNT (Wingless-INT) signalling pathway. Among them, we identified the nearby Wnt7b gene as a direct Lnc-Rewind target. We show that Lnc-Rewind interacts with the G9a histone lysine methyltransferase and mediates the in cis repression of Wnt7b by H3K9me2 deposition. Overall, these findings provide novel insights into the epigenetic regulation of adult muscle stem cells fate by lncRNAs.
Identifiants
pubmed: 33432928
doi: 10.7554/eLife.54782
pii: 54782
pmc: PMC7837680
doi:
pii:
Substances chimiques
RNA, Long Noncoding
0
Banques de données
GEO
['GSE141396', 'GSE70389']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Cipriano et al.
Déclaration de conflit d'intérêts
AC, MM, GB, TS, BB, GP, AC, CM, MB No competing interests declared
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