Changes in proteins related to early nerve repair in a rat model of sciatic nerve injury.

Wallerian degeneration animal model cell generation chemotaxis clamp injury inflammation injury neurotrophic factor peripheral nerve protein array repair sciatic nerve

Journal

Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351

Informations de publication

Date de publication:
Aug 2021
Historique:
entrez: 12 1 2021
pubmed: 13 1 2021
medline: 13 1 2021
Statut: ppublish

Résumé

Peripheral nerves have a limited capacity for self-repair and those that are severely damaged or have significant defects are challenging to repair. Investigating the pathophysiology of peripheral nerve repair is important for the clinical treatment of peripheral nerve repair and regeneration. In this study, rat models of right sciatic nerve injury were established by a clamping method. Protein chip assay was performed to quantify the levels of neurotrophic, inflammation-related, chemotaxis-related and cell generation-related factors in the sciatic nerve within 7 days after injury. The results revealed that the expression levels of neurotrophic factors (ciliary neurotrophic factor) and inflammation-related factors (intercellular cell adhesion molecule-1, interferon γ, interleukin-1α, interleukin-2, interleukin-4, interleukin-6, monocyte chemoattractant protein-1, prolactin R, receptor of advanced glycation end products and tumor necrosis factor-α), chemotaxis-related factors (cytokine-induced neutrophil chemoattractant-1, L-selectin and platelet-derived growth factor-AA) and cell generation-related factors (granulocyte-macrophage colony-stimulating factor) followed different trajectories. These findings will help clarify the pathophysiology of sciatic nerve injury repair and develop clinical treatments of peripheral nerve injury. This study was approved by the Ethics Committee of Peking University People's Hospital of China (approval No. 2015-50) on December 9, 2015.

Identifiants

DOI: 10.4103/1673-5374.301025 PMID: 33433493 PMC: PMC8323673
pubmed: 33433493
pii: NeuralRegenRes_2021_16_8_1622_301025
doi: 10.4103/1673-5374.301025
pmc: PMC8323673
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1622-1627

Déclaration de conflit d'intérêts

None

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Auteurs

Yu-Song Yuan (YS)

Department of Trauma and Orthopedics, Peking University People's Hospital; Key Laboratory of Trauma and Neural Regeneration (Peking University), Ministry of Education, Beijing, China.

Fei Yu (F)

Department of Trauma and Orthopedics, Peking University People's Hospital, Beijing; National & Local Joint Engineering Research Center of Orthopedic Biomaterials, Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.

Ya-Jun Zhang (YJ)

National Center for Trauma Medicine, Beijing, China.

Su-Ping Niu (SP)

Office of Academic Research, Peking University People's Hospital, Beijing, China.

Hai-Lin Xu (HL)

Department of Trauma and Orthopedics; Diabetic Foot Treatment Center, Peking University People's Hospital, Beijing, China.

Yu-Hui Kou (YH)

Department of Trauma and Orthopedics, Peking University People's Hospital; Key Laboratory of Trauma and Neural Regeneration (Peking University), Ministry of Education, Beijing, China.

Classifications MeSH