Tract-specific analysis and neurocognitive functioning in sickle cell patients without history of overt stroke.

Anemia, Sickle Cell / complications Corpus Callosum Diffusion Tensor Imaging Humans Stroke / diagnostic imaging White Matter
microstructural damage neurocognitive sickle cell disease tract-specific analysis white matter

Journal

Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837

Informations de publication

Date de publication:
03 2021
Historique:
revised: 05 10 2020
received: 04 12 2019
accepted: 27 10 2020
pubmed: 13 1 2021
medline: 1 7 2021
entrez: 12 1 2021
Statut: ppublish

Résumé

Sickle cell disease (SCD) is a hereditary blood disorder in which the oxygen-carrying hemoglobin molecule in red blood cells is abnormal. SCD patients are at increased risks for strokes and neurocognitive deficit, even though neurovascular screening and treatments have lowered the rate of overt strokes. Tract-specific analysis (TSA) is a statistical method to evaluate microstructural WM damage in neurodegenerative disorders, using diffusion tensor imaging (DTI). We utilized TSA and compared 11 major brain WM tracts between SCD patients with no history of overt stroke, anemic controls, and healthy controls. We additionally examined the relationship between the most commonly used DTI metric of WM tracts and neurocognitive performance in the SCD patients and healthy controls. Disruption of WM microstructure orientation-dependent metrics for the SCD patients was found in the genu of the corpus callosum (CC), cortico-spinal tract, inferior fronto-occipital fasciculus, right inferior longitudinal fasciculus, superior longitudinal fasciculus, and left uncinate fasciculus. Neurocognitive performance indicated slower processing speed and lower response inhibition skills in SCD patients compared to controls. TSA abnormalities in the CC were significantly associated with measures of processing speed, working memory, and executive functions. Decreased DTI-derived metrics were observed on six tracts in chronically anemic patients, regardless of anemia subtype, while two tracks with decreased measures were unique to SCD patients. Patients with WMHs had more significant FA abnormalities. Decreased FA values in the CC significantly correlated with all nine neurocognitive tests, suggesting a critical importance for CC in core neurocognitive processes.

Identifiants

DOI: 10.1002/brb3.1978 PMID: 33434353 PMC: PMC7994688
pubmed: 33434353
doi: 10.1002/brb3.1978
pmc: PMC7994688
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e01978

Informations de copyright

© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC.

Références

Am J Med Sci. 1948 Jul;216(1):11-9
pubmed: 18877309
Blood. 2011 Jan 27;117(4):1130-40; quiz 1436
pubmed: 21068435
Br J Haematol. 2016 Jan;172(2):274-84
pubmed: 26492630
Neurology. 2014 Mar 11;82(10):835-41
pubmed: 24523480
Neuropsychol Rev. 2006 Mar;16(1):17-42
pubmed: 16794878
Lancet. 2010 Dec 11;376(9757):2018-31
pubmed: 21131035
N Engl J Med. 1998 Jul 2;339(1):5-11
pubmed: 9647873
Neurology. 2001 Apr 24;56(8):1109-11
pubmed: 11320190
J Int Neuropsychol Soc. 2009 May;15(3):383-93
pubmed: 19402924
J Neurol. 2008 Mar;255(3):360-6
pubmed: 18338199
Blood. 2016 Apr 21;127(16):2038-40
pubmed: 26941400
Arch Clin Neuropsychol. 2006 Feb;21(2):167-74
pubmed: 16242906
Magn Reson Med. 2011 Jun;65(6):1532-56
pubmed: 21469191
Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:889-892
pubmed: 30344893
Am J Hematol. 2019 Apr;94(4):467-474
pubmed: 30697803
Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R1105-14
pubmed: 16322350
IEEE Trans Med Imaging. 2006 Dec;25(12):1547-64
pubmed: 17167991
JAMA. 2010 May 12;303(18):1823-31
pubmed: 20460621
Neuroimage. 2016 Feb 15;127:158-172
pubmed: 26691524
Pediatr Blood Cancer. 2011 May;56(5):783-8
pubmed: 21370411
Blood. 2015 Mar 5;125(10):1653-61
pubmed: 25533032
Neuroreport. 1999 Sep 9;10(13):2817-21
pubmed: 10511446
Neurosci Biobehav Rev. 2014 May;42:180-92
pubmed: 24568942
Neuroreport. 2015 Dec 16;26(18):1151-4
pubmed: 26559727
Med Image Anal. 2006 Oct;10(5):764-85
pubmed: 16899392
Cortex. 2010 May;46(5):691-9
pubmed: 19775684
Neurology. 2018 Jun 5;90(23):e2042-e2050
pubmed: 29752305
J Int Neuropsychol Soc. 2007 Jan;13(1):99-107
pubmed: 17166308
Blood. 2016 Feb 18;127(7):829-38
pubmed: 26758917
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Mar;4(3):233-242
pubmed: 30478002
Magn Reson Med. 2015 Dec;74(6):1768-79
pubmed: 25447208
Neuroimage Clin. 2017 Apr 29;15:239-246
pubmed: 28540180
Dev Med Child Neurol. 2018 May;60(5):520-526
pubmed: 29488622
J Child Neurol. 2002 Dec;17(12):891-5
pubmed: 12593461
Neuroradiology. 2004 May;46(5):339-50
pubmed: 15103435
Am J Hematol. 2014 Oct;89(10):E188-92
pubmed: 25042018
J Adv Nurs. 2016 Jun;72(6):1409-16
pubmed: 26289301
Neuroimage. 2009 Mar;45(1 Suppl):S99-110
pubmed: 19059348
AJNR Am J Neuroradiol. 2012 Dec;33(11):2043-9
pubmed: 22595904
Neuroimage Clin. 2013 Jun 19;2:854-61
pubmed: 24179837
Neuroimage. 2003 Oct;20(2):870-88
pubmed: 14568458
Eur Radiol. 2013 Jul;23(7):1946-55
pubmed: 23404139
J Child Neurol. 2006 Jan;21(1):37-44
pubmed: 16551451
Neuroimage. 2006 Jul 15;31(4):1487-505
pubmed: 16624579
Radiology. 2002 Jan;222(1):212-8
pubmed: 11756728
Front Hum Neurosci. 2018 Apr 13;12:127
pubmed: 29706875
Pediatrics. 1996 Jun;97(6 Pt 1):864-70
pubmed: 8657528
Hum Brain Mapp. 2013 Jan;34(1):77-95
pubmed: 21954054
Neuroimage. 2017 Aug 15;157:675-694
pubmed: 28457976
Neuroimage. 2008 Aug 15;42(2):1032-44
pubmed: 18602840
J Pediatr Psychol. 2004 Apr-May;29(3):185-95
pubmed: 15131136
Neuroimage. 2008 Jan 1;39(1):62-79
pubmed: 17919935
J Magn Reson B. 1994 Mar;103(3):247-54
pubmed: 8019776
AJNR Am J Neuroradiol. 2003 Mar;24(3):382-9
pubmed: 12637286
AJNR Am J Neuroradiol. 2005 Mar;26(3):455-62
pubmed: 15760849
Brain Struct Funct. 2013 Jan;218(1):21-37
pubmed: 22200882
BMJ. 1998 Dec 19-26;317(7174):1673-4
pubmed: 9857119
Lancet. 2013 Jan 12;381(9861):142-51
pubmed: 23103089
Neuropsychology. 2004 Jul;18(3):564-71
pubmed: 15291734
IEEE Trans Med Imaging. 2010 Aug;29(8):1504-15
pubmed: 20562045
Hum Brain Mapp. 2013 Oct;34(10):2464-83
pubmed: 22488973
IEEE Trans Med Imaging. 2007 Nov;26(11):1585-97
pubmed: 18041273
N Engl J Med. 2014 Aug 21;371(8):699-710
pubmed: 25140956
Am J Hematol. 2019 Oct;94(10):1055-1065
pubmed: 31259431
Br J Haematol. 2015 Feb;168(4):553-6
pubmed: 25303108
Med Image Comput Comput Assist Interv. 2007;10(Pt 2):211-8
pubmed: 18044571
J Pediatr Psychol. 2018 Jun 1;43(5):543-551
pubmed: 29155970
Stroke. 2015 Jul;46(7):1793-9
pubmed: 25967572
Hum Brain Mapp. 2002 Jan;15(1):1-25
pubmed: 11747097
Neuroimage. 2008 Jun;41(2):448-61
pubmed: 18407524
Ann Neurol. 2006 Apr;59(4):662-72
pubmed: 16450382
J Child Neurol. 2008 Oct;23(10):1160-71
pubmed: 18952582
Blood. 2018 Oct 18;132(16):1714-1723
pubmed: 30061156
J Pediatr Psychol. 2019 Sep 1;44(8):948-958
pubmed: 31050352
J Neurol Neurosurg Psychiatry. 1999 Nov;67(5):661-3
pubmed: 10519876
Blood. 2012 May 17;119(20):4587-96
pubmed: 22354000
J Dev Behav Pediatr. 2012 Apr;33(3):244-51
pubmed: 22343483
Blood. 1998 Jan 1;91(1):288-94
pubmed: 9414296
Proc SPIE Int Soc Opt Eng. 2015 Nov;9681:
pubmed: 30344363
Brain Behav. 2021 Mar;11(3):e01978
pubmed: 33434353
AJR Am J Roentgenol. 2012 May;198(5):1167-74
pubmed: 22528909

Auteurs

Yaqiong Chai (Y)

CIBORG Laboratory, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
ORCID: 0000-0003-4175-6720

Chaoran Ji (C)

CIBORG Laboratory, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Department of Electrical Engineering, University of Southern California, Los Angeles, CA, USA.

Julie Coloigner (J)

CIBORG Laboratory, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
ORCID: 0000-0001-7774-8015

Soyoung Choi (S)

Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.

Melissa Balderrama (M)

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Division of Hematology, Oncology, and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Chau Vu (C)

Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.

Benita Tamrazi (B)

Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Thomas Coates (T)

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Division of Hematology, Oncology, and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA, USA.

John C Wood (JC)

Division of Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Sharon H O'Neil (SH)

Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Division of Neurology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.

Natasha Lepore (N)

CIBORG Laboratory, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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Classifications MeSH

questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Hémoglobinopathies › Drépanocytose › Tract-specific analysis and neurocognitive...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Commissures du télencéphale › Corps calleux › Tract-specific analysis and neurocognitive...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Imagerie par tenseur de diffusion › Tract-specific analysis and neurocognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tract-specific analysis and neurocognitive...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Tract-specific analysis and neurocognitive...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance blanche › Tract-specific analysis and neurocognitive...