Hypoxia: Uncharged tRNA to the Rescue!

Amino Acyl-tRNA Synthetases / genetics Animals Caenorhabditis elegans / genetics Hypoxia / genetics RNA, Transfer / genetics Threonine-tRNA Ligase

Journal

Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782

Informations de publication

Date de publication:
11 01 2021
Historique:
entrez: 12 1 2021
pubmed: 13 1 2021
medline: 16 7 2021
Statut: ppublish

Résumé

A new study has identified genes that protect Caenorhabditis elegans from hypoxic stress. Genomic approaches and whole-organism proteomics reveal a regulatory interaction between a threonyl-tRNA synthetase and ribosome biogenesis that modulates global translation and hypoxic sensitivity.

Identifiants

DOI: 10.1016/j.cub.2020.10.067 PMID: 33434482
pubmed: 33434482
pii: S0960-9822(20)31610-9
doi: 10.1016/j.cub.2020.10.067
pii:
doi:

Substances chimiques

RNA, Transfer 9014-25-9
Amino Acyl-tRNA Synthetases EC 6.1.1.-
Threonine-tRNA Ligase EC 6.1.1.3

Types de publication

Editorial Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

R25-R27

Subventions

Organisme : Medical Research Council
ID : MC_UP_A600_1023
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00025/7
Pays : United Kingdom

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Thomas E Mulroney (TE)

MRC Toxicology Unit, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QW, UK. Electronic address: tem37@cam.ac.uk.

Tuija Pöyry (T)

MRC Toxicology Unit, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QW, UK.

Anne E Willis (AE)

MRC Toxicology Unit, University of Cambridge, Tennis Court Rd, Cambridge CB2 1QW, UK. Electronic address: aew80@cam.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-oxygen ligases › Amino acyl-tRNA synthetases › Hypoxia: Uncharged tRNA to the Rescue!
questionsmedicales.fr › Eucaryotes › Animaux › Hypoxia: Uncharged tRNA to the Rescue!
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Caenorhabditis › Caenorhabditis elegans › Hypoxia: Uncharged tRNA to the Rescue!
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Hypoxia: Uncharged tRNA to the Rescue!
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN de transfert › Hypoxia: Uncharged tRNA to the Rescue!
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-oxygen ligases › Amino acyl-tRNA synthetases › Threonine-tRNA ligase › Hypoxia: Uncharged tRNA to the Rescue!