Effects of Transanal Irrigation on Gut Microbiota in Pediatric Patients with Spina Bifida.
constipation
gut microbiota
spina bifida
transanal irrigation
urinary tract infection
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
10 Jan 2021
10 Jan 2021
Historique:
received:
13
12
2020
revised:
30
12
2020
accepted:
05
01
2021
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
14
1
2021
Statut:
epublish
Résumé
Recent studies using 16S rRNA-based microbiota profiling have demonstrated dysbiosis of gut microbiota in constipated patients. The aim of this study was to investigate the changes in gut microbiota after transanal irrigation (TAI) in patients with spina bifida (SB). A questionnaire on neurogenic bowel disfunction (NBD), Bristol scale, and gut microbiota using 16S rRNA sequencing were completed in 16 SB patients and 10 healthy controls aged 6-17 years. Then, 11 of 16 SB patients with moderate to severe NBD scores received TAI for 3 months. Changes in urine cultures were also examined before and after the TAI treatments. In addition, correlation of gut microbiota and Bristol scale was analyzed. Significantly decreased abundance in
Identifiants
pubmed: 33435163
pii: jcm10020224
doi: 10.3390/jcm10020224
pmc: PMC7827399
pii:
doi:
Types de publication
Journal Article
Langues
eng
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