The Protective Role of Alpha-Ketoglutaric Acid on the Growth and Bone Development of Experimentally Induced Perinatal Growth-Retarded Piglets.
bone
glucocorticoid
perinatal growth-retardation
pigs
α-ketoglutaric acid
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
10 Jan 2021
10 Jan 2021
Historique:
received:
23
12
2020
revised:
07
01
2021
accepted:
08
01
2021
entrez:
13
1
2021
pubmed:
14
1
2021
medline:
14
1
2021
Statut:
epublish
Résumé
The effect of alpha-ketoglutaric acid (AKG) supplementation to experimentally-induced, perinatal growth-retarded piglets was examined. Sows were treated with a synthetic glucocorticoid (Gc) during the last 25 days of pregnancy, and after the birth, piglets were randomly divided into three groups depending on the treatment. The Gc/Gc + AKG and Gc/AKG groups born by Gc-treated sows after the birth were treated with Gc or Gc + AKG for 35 days. Significantly lower serum growth hormone, IGF-I, osteocalcin, leptin, and cortisol concentrations were observed in the Gc/Gc + AKG group, while the bone alkaline phosphatase activity was significantly higher. Serum insulin concentration was higher in the control group. Serum alanine, lysine, histidine, and tryptophan concentrations were higher in the Gc/Gc + AKG and Gc/AKG groups. The perinatal action of Gc significantly affects histomorphometry of articular cartilage and trabecular bone and bone mechanics. The results clearly showed that dietary AKG had positive effects with regards to the profile of free amino acids. Taking into account the function of AKG as an energy donor and stimulator of collagen synthesis, it can be concluded that the anabolic role of AKG may be the main mechanism responsible for its protective effect against the GC-induced perinatal intensified catabolic state.
Identifiants
pubmed: 33435211
pii: ani11010137
doi: 10.3390/ani11010137
pmc: PMC7826854
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Mol Cell Endocrinol. 2001 Dec 20;185(1-2):135-44
pubmed: 11738803
Proc Nutr Soc. 1998 Feb;57(1):113-22
pubmed: 9571716
J Physiol Pharmacol. 2012 Oct;63(5):547-54
pubmed: 23211309
Hepatology. 2005 Feb;41(2):380-2
pubmed: 15660433
Pediatr Res. 2001 Nov;50(5):618-23
pubmed: 11641457
Mol Med Rep. 2014 Aug;10(2):579-84
pubmed: 24859417
Brain Res. 1999 Nov 6;846(2):236-42
pubmed: 10556641
Growth Horm IGF Res. 2006 Aug;16(4):267-75
pubmed: 16920374
J Anim Physiol Anim Nutr (Berl). 2002 Aug;86(7-8):239-45
pubmed: 15379910
J Anim Physiol Anim Nutr (Berl). 2009 Apr;93(2):192-202
pubmed: 19320932
J Clin Endocrinol Metab. 2001 Feb;86(2):935-8
pubmed: 11158070
Arch Intern Med. 1999 May 10;159(9):941-55
pubmed: 10326936
Amino Acids. 2013 Sep;45(3):407-11
pubmed: 23595206
Reproduction. 2001 Jun;121(6):853-62
pubmed: 11373171
J Physiol. 2000 Jul 15;526 Pt 2:409-16
pubmed: 10896729
Best Pract Res Clin Endocrinol Metab. 2002 Sep;16(3):399-419
pubmed: 12464225
Exp Biol Med (Maywood). 2016 Jan;241(1):14-24
pubmed: 26202375
J Nutr. 1999 May;129(5):1031-8
pubmed: 10222396
Nutrition. 2012 Feb;28(2):190-6
pubmed: 22018909
J Anim Physiol Anim Nutr (Berl). 2013 Aug;97(4):785-96
pubmed: 22716040
J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 1;879(29):3108-21
pubmed: 21524944
J Anim Physiol Anim Nutr (Berl). 2010 Jun;94(3):293-306
pubmed: 19663986
Am J Obstet Gynecol. 1976 Dec 1;126(7):931-41
pubmed: 187057
Biomol Ther (Seoul). 2016 Jan;24(1):1-8
pubmed: 26759695
Semin Neonatol. 2001 Aug;6(4):309-17
pubmed: 11972432
J Matern Fetal Neonatal Med. 2006 Aug;19(8):489-93
pubmed: 16966114
Nutrition. 2013 Mar;29(3):556-61
pubmed: 23218481
Cell. 2007 Aug 10;130(3):456-69
pubmed: 17693256
Ann Allergy Asthma Immunol. 2008 Jan;100(1):23-30
pubmed: 18254478
Can J Vet Res. 1986 Apr;50(2):205-8
pubmed: 3756675
Neurosci Biobehav Rev. 2005 Apr;29(2):283-94
pubmed: 15811499
Indian J Biochem Biophys. 1989 Dec;26(6):371-6
pubmed: 2632360
Am J Med. 2004 Aug 1;117(3):204-7
pubmed: 15300973
Nutrition. 2001 Jan;17(1):35-40
pubmed: 11165886
J Physiol Pharmacol. 2014 Feb;65(1):107-15
pubmed: 24622835
Int J Tryptophan Res. 2009 Mar 23;2:45-60
pubmed: 20651948
Animals (Basel). 2020 Apr 22;10(4):
pubmed: 32331362
Semin Neonatol. 2001 Aug;6(4):285-92
pubmed: 11972430
Berl Munch Tierarztl Wochenschr. 2010 Sep-Oct;123(9-10):397-405
pubmed: 21038811
Mol Cell. 2014 Oct 23;56(2):205-218
pubmed: 25242145
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Curr Opin Pharmacol. 2001 Dec;1(6):632-40
pubmed: 11757820
Bone. 2006 Jul;39(1):100-5
pubmed: 16469550
Poult Sci. 2005 Oct;84(10):1604-9
pubmed: 16335130
Osteoarthritis Cartilage. 2003 Dec;11(12):864-71
pubmed: 14629962
J Bone Miner Res. 2002 Feb;17(2):200-9
pubmed: 11811550
Hypertension. 1996 Jun;27(6):1200-4
pubmed: 8641724
J Vet Med Sci. 2016 May 3;78(4):563-71
pubmed: 26725871
Br J Nutr. 2013 Aug;110(4):651-8
pubmed: 23308390
Lancet. 1995 May 20;345(8960):1277-8
pubmed: 7746060
Early Hum Dev. 1997 Feb 20;47(3):271-86
pubmed: 9088794
Steroids. 1997 Jan;62(1):89-94
pubmed: 9029721
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5621-5
pubmed: 9576933
J Nutr. 2001 Sep;131(9 Suppl):2569S-77S; discussion 2590S
pubmed: 11533315
FASEB J. 1996 Jun;10(8):829-37
pubmed: 8666159
Connect Tissue Res. 2015 Nov;56(6):483-92
pubmed: 26305209
Curr Opin Clin Nutr Metab Care. 2003 May;6(3):277-82
pubmed: 12690259
Cell Metab. 2018 Nov 6;28(5):721-736.e6
pubmed: 30122553
Biochim Biophys Acta. 1991 May 17;1092(3):376-83
pubmed: 1675589
Domest Anim Endocrinol. 2001 Aug;21(2):97-109
pubmed: 11585700
Exp Biol Med (Maywood). 2017 Apr;242(7):671-682
pubmed: 28178857
Poult Sci. 2017 Feb 1;96(2):491-500
pubmed: 27591270
Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E83-9
pubmed: 10644540
Reprod Fertil Dev. 1995;7(3):351-63
pubmed: 8606944
Am J Physiol. 1999 Feb;276(2):E269-77
pubmed: 9950786
Physiol Behav. 1999 Dec 1-15;68(1-2):145-50
pubmed: 10627073
Domest Anim Endocrinol. 2003 Apr;24(3):193-208
pubmed: 12642160
Br J Nutr. 1986 May;55(3):659-68
pubmed: 3676183
Braz J Med Biol Res. 2003 Feb;36(2):153-63
pubmed: 12563517
Mol Cell Endocrinol. 2001 Dec 20;185(1-2):61-71
pubmed: 11738795
J Anim Physiol Anim Nutr (Berl). 2018 Feb;102(1):e299-e308
pubmed: 28503899
J Endocrinol. 1996 Oct;151(1):97-105
pubmed: 8943773
Nutrition. 1998 Nov-Dec;14(11-12):870-3
pubmed: 9834933
Am J Obstet Gynecol. 1998 May;178(5):880-5
pubmed: 9609554
Nat Rev Mol Cell Biol. 2005 Nov;6(11):838-49
pubmed: 16261189
Cell. 2010 Jul 23;142(2):296-308
pubmed: 20655470